AI overview: The pathophysiology of the psychopathic brain involves structural & functional abnormalities, particularly in the prefrontal cortex & limbic system, leading to deficits in emotion processing & social behaviour. Studies show reduced gray matter volume & functional connectivity in areas like the amygdala & ventromedial prefrontal cortex, impairing communication & regulation of fear, empathy & guilt. Structural differences •Gray matter volume: individuals with psychopathy often show reduced gray matter volume in the prefrontal cortex, limbic areas (amygdala, hippocampus & insula) & paralimbic regions. White matter integrity: some research has found reduced white matter integrity in the connections between brain regions, particularly in the uncinate fasciculus & cingulate bundle, which are critical for emotional regulation. Functional differences: Prefrontal cortex & limbic system disconnect: A key finding is …

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