🫁 Honored to be featured as the next Pulmonary Fibrosis Expert in the Three Lakes 12-20 #AskTheExpert series!
Patients, family members, researchers, trainees, submit questions by April 10th & I'll answer your questions!
#CurePF4All
#ThreeLakes1220
www.threelakes1220.org/ask-the-expert

Inhaled Treprostinil for Idiopathic Pulmonary Fibrosis | NEJM Preclinical data indicate that inhaled treprostinil may be useful for the treatment of idiopathic pulmonary fibrosis (IPF) through an antifibrotic mechanism, a premise that is supported by clinical...

After a negative decade - finally a good year for IPF patients - Inhaled Treprostinil associated with a smaller decline in FVC & fewer clinical-worsening events (but also ~30%). Still no improvement - but let’s all hope momentum continues #CurePF4ALL www.nejm.org/doi/full/10....

After a long time I remade my office Zoom background - and I really like it - especially the Texas #CureIPF license plate. And yes, one day we’ll get there!
#CurePF4All

Even at times like that, when reason, science, medicine and human solidarity are under attack - there is hope - I had a great time visiting the super team at Tulane, giving two talks, seeing old friends, acquiring new ones - and discussing #CurePF4All
#ScienceMatters
##CureIPF
#AcademicNomads

Megakaryocytes def have a role in haematological myeloproliferative disorders in bone marrow fibrosis, producing TGFb, FGF…

(Can we resurrect #CurePF4all ?? 🍀)

Do megakaryocytes contribute to organ fibrosis? Abstract. Megakaryocytes, the platelet precursors, have been known to populate tissues other than the bone marrow, most prominently the lung, but also the

Rephrasing question to revive #CurePF4All convo here: Do megakaryocytes contribute to Pulmonary Fibrosis?
What think you @ipfdoc.bsky.social @drpujamehta1.bsky.social @knipelab.bsky.social @elizabethredente.bsky.social @ild-ipfdoc.bsky.social @kerrijohannson.bsky.social
@drdayjee.bsky.social ?

Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness Epigenetic control of gene expression and cellular phenotype is influenced by changes in the local microenvironment, yet how mechanical cues precisely influence epigenetic state to regulate transcript...

Really coool. And very relevant tk Pulmonary Fibrosis
#ScienceMatters
#CurePF4All
www.science.org/doi/10.1126/...

A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases - Nature Biomedical Engineering UNAGI deciphers cellular dynamics from human disease time-series single-cell data and facilitates in silico drug perturbations to discover drugs potentially active against complex human diseases.

Always a pleasure to see the paper come out in print & this one is very special because it indicates how Pulmonary Fibrosis drug discovery can be liberated from Col1A1, ASMA, using AI, human & PCLS scRNAseq data
Kudos Drs Zheng and Ding #CurePF4ALL
www.nature.com/articles/s41...

So glad I found the time to attend the Nature Conference ׳Cracking the Code: Nucleic Acid Medicines Coming of Age׳ - amazing talks and very appealing novel RNA therapeutic - very relevant to #CurePF4All.
#RNARocks
#ScienceMatters

We make our speakers work really hard! 2 talks, many meetings, meals and this time our holiday party!
And it paid again!
What a Tour De Force visit by Prof Jenkins @ipfdoc.bsky.social - great, great talks, challenges to PF orthodoxies , inspiring discussions!
#YaleGreatTalks #CurePF4All

Dysregulated alveolar type 2 epithelial cell proteostasis promotes fibrogenic macrophage migration inhibitory factor–CD74 signaling Impaired proteostasis amplifies alveolar epithelial MIF signaling to macrophages, increasing profibrotic macrophages and driving lung fibrosis.

Is MIF the missing link between AT2 & macrophages in Pulmonary Fibrosis?
See "Dysregulated Alveolar type 2 epithelial cell proteostasis promotes fibrogenic macrophage migration inhibitory factor–CD74 signaling"
Kudos Drs Kim, Sauler & team!
#CurePF4All
www.science.org/doi/10.1126/...

Finally in Print! The Official ATS Research Statement on Racial, Ethnic, Sex & Gender Equity for Inclusive Interstitial Lung Disease Research.
👏🏼 Drs Assayag, Adegonsoye, Cottin, Mageto & @atsblueeditor.bsky.social & @atscommunity.bsky.social
#CurePF4All
www.atsjournals.org/doi/10.1164/...

I don’t usually attend immunocardiology conferences - but when I do - I enjoy doing it in gorgeous locations with amazing colleagues & early career researchers & shamelessly proselytize for lung fibrosis research & awareness.
Love seeing the progress & enthusiasm!!
#CurePF4All
#ScienceMatters

hen it rains it pours!! What an amazing #ATS2025 for #CurePF4ALL! Nerandomilast -> ⬇️FVC decline compared to placebo in Progressive Pulmonary Fibrosis patients on antifibrotics or untreated. 👏🏼 Drs Maher, Martinez & #FibroneerILD team!!
www.nejm.org/doi/full/10....

Finally! The Pulmonary Fibrosis Drug Connectome is on #IPFCellAtlas!! If you want to know if a drug is antifibrotic, which cells it targets, or what drugs target a gene you like, in what cells - go to ipfcellatlas.com click on the Connectome tab. Enjoy - It's Free!!!
#DataSharing
#CurePF4All

To all interested in all things related to Pulmonary Fibrosis - the #CureFibrosis starter pack is ready for 2025 - please let me know if you wish to be included and ofcourse follow - use #CurePF4All #CureIPF #CureFibrosis etc
#HappyNewYear
go.bsky.app/6hgNDdr

OMG - just noticed that #YalePCCSM are getting a unique #CUREPF4ALL treat before the Holidays! Two talks by one of my fav #DemistifyPF researchers in the world, Dr. Jonathan Kropski.
#GreatYaleTalks
#ThisIsYalePCCSM

Had a great time visiting long time collaborators & friends at Southampton University Hospital. Superb discussions about TB, scarring, IPF, new insights, collaborations. It was last talk on my 2024 transatlantic excursion & it was refreshing & energizing!
🙏🏼Prof Jones🙏🏼
#AcademicNomads
#CurePF4All

Honored and excited to be selected to give the Fergus Goodbody Memorial Lecture for the Irish Lung Fibrosis Foundation and the Irish Thoracic this year!
🙏🏼@ILFA_Ireland & @irishthoracicS🙏🏼
#CurePF4All