C-terminal domain dimerization in yeast Hsp90 is moderately modulated by the other domains Heat shock protein 90 (Hsp90) serves as a crucial regulator of cellular proteostasis by stabilizing and regulating the activity of numerous substrates, many of which are oncogenic proteins. Therefore,...

With growing interest in Hsp90 CTD inhibitors here's a reminder of our CTD study on yeast Hsp90. We showed the NTD and MD to modulate CTD dimerization and shape allostery; super relevant for CTD-targeted drug design #Hsp90 #allostery #DugDesign #Biophysics
www.cell.com/biophysj/ful...