We discover the kinase #Dyrk3 and the known centriole linker #cNAP1 as critical components to prevent centrosome breakage during these deformations

& identify #forces from the actin cytoskeleton as causative forces leading to rapid #fracturing of the centriolar pair at the centrosomal core.

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Excited to share our discovery www.science.org/doi/10.1126/...

that the #centrosome is prone to breakage!

Using #motile cells, we identify centrosome breakage during #pathfinding, caused by #actin #forces, & prevented by #Dyrk3

Kudos to 1st author Madeleine & thanks to all collaborators!

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