PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease Recent discoveries reveal that post-translational modifications (PTMs) do more than regulate protein activity – they encode conformational states that…

💡Have you checked out our latest review in @cp-trendsbiochem.bsky.social? Discover how post-translational modifications can convert molecular chaperones into #epichaperomes – stable scaffolds that restructure protein–protein interaction networks in disease #PPI
www.sciencedirect.com/science/arti...

Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum Alzheimer’s disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we pr...

How do stressors remodel #brain function before symptoms emerge? &network-centric intervention strategies as a promising avenue for disease-modifying #therapy in AD
#Alzheimers #epichaperomes #neuroscience #SystemsBiology #networkbiology #drugdiscovery
www.researchsquare.com/article/rs-5...

Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum Alzheimer’s disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we pr...

💫Preprint available now! Our most recent research on #Alzheimers and #epichaperomes is below. Read to find out how #epichaperomes are key mediators of molecular collapse in #AD & what avenues are promising for disease-modifying #therapies🧠
www.researchsquare.com/article/rs-5...

Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum Alzheimer’s disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we pr...

How do stressors remodel brain function before symptoms emerge?
💫Preprint live now - our most recent research on #Alzheimers & #epichaperomes! Find out how #epichaperomes are key mediators of molecular collapse in #AD & what #therapeutic avenues may be open 🧠
www.researchsquare.com/article/rs-5...