#erythrovirus #parvovirus IgG and IgM antibody may be negative in a large fraction in PLWH Thus, PCR would be useful diagnostically. This viral infection is controlled in normal hosts by humoral immunity. Thus their red cell aplasia is only transient.
In immunosuppressed patients, nucleic acid amplification tests of blood are most useful to detect #erythrovirus B19 infection. In this case: Serum PCR+ Infection acquired from school kids.
Giant abnormal pronormoblasts on bone marrow biopsy, when present, are also diagnostic.
Severe anemia but no clear evidence of hemolysis (normal LDH, no gastrointestinal blood loss) likely has #Erythrovirus (also called #Parvovirus) B19 infection. Ref GWIDBR Pic Ref www.nejm.org/doi/full/10....
