Summary figure details changes in ether lipid metabolism in obesity as indicated by the lipid ratios, liver micro-array data, and GWAS analysis. Coloured text depicts potential changes in enzymatic activity (green: increase; red: decrease), identified through linear regression analysis, adjusting for age and sex, of 82 lipid ratios and waist circumference in the AusDiab cohort (n = 10,399). Lipid ratios were log2 transformed, mean-centered and scaled to standard deviation. p-values were corrected for multiple comparisons using the false discovery rate method of Benjamini and Hochberg. Scatter plots depict consolidated liver micro-array data of male mice across 74 matched strains (n = 2−3 per strain) after either a high-fat/high-sugar (navy, n = 152) or chow (blue, n = 222) diet for eight weeks.
#Lipidomic profiling has linked plasma #EtherLipids with #obesity. This study analyzes a set of biologically informed lipid ratios to reveal obesity-related alterations in enzymatic activity & #GeneticVariants not apparent in traditional lipidomic analyses @plosbiology.org 🧪 plos.io/41vdrO5