Top left: Illustration showing the location of Utah arrays implanted into FPC of M1 (32 channels, blue) and M2 (64 channels, red); poststudy analysis confirmed both arrays implanted in the most rostro-lateral portion of FPC, with the entire array located rostral to the anterior tip of Principal Sulcus. Top right: Choice-aligned spectrogram showing a strong gamma frequency response (top). Array maps showing choice responses across the arrays implanted in M1 (blue) and M2 (red). Electrodes with significant gamma responses aligned to choices outlined in cyan. Red crosses indicate reference electrodes. Bottom left: Example spectrograms showing choice-aligned activity recorded from FPC following high-frequency stimulation (upper) or in the absence of stimulation (lower). Spectrogram calculated by averaging over the fifth to eighth trials after stimulation. Nonstimulation spectrogram calculated from the average spectrograms of trials from the last four trials of four nonstimulated blocks (i.e., same relative block epoch). White box indicates the 400 ms period used for further analysis. Bottom right: Illustration of the trials included in the analysis of changes in LFP activity recorded from FPC caused by electrical microstimulation. In stimulation blocks, the 10 trials before and 10 trials after the poststimulation block change were included (white box). In nonstimulation blocks a corresponding window of trials was selected.
What's the role of #FrontopolarCortex (FPC) in evaluating alternative goals? @markboxf.bsky.social &co show that FPC activity tracks the value of #counterfactual rules via gamma & beta bursts; targeted FPC stimulation alters both neural signals & #DecisionMaking @plosbiology.org 🧪 plos.io/4ppd5lL
