Three new cases reported on using artificial oxygen carriers, by Dr Zhen Mei (UCLA, US).
HBOC-201 was successfully used on sickle cell disease patients as bridge therapy and/or as substitute for allogeneic blood transfusion.
doi.org/10.1097/MJT....
🧪 #MedSky #HBOCs
Title and image of the news article: at blande blod. With an image of dried red powder slowly droplet-wise changing into a red blood-like liquid.
Weekendavisen just published an article regarding artificial blood substitutes, with an interview with Prof. Leticia Hosta-Rigau at DTU Health Tech.
Very nice to see our research reach the Danish news!
www.weekendavisen.dk/2025-04/idee...
🧪👩🔬 #HBOCs #AcademicSky
Paper: Scalable production and biophysical characterization of high-molecular-weight relaxed and tense quartenary state polymerized human hemoglobin as potential red blood cell substitutes, published in BioMacroMolecules. Table 1 (partially) shows the biophysical properties of the hHb and polyhHb’s tested in this study itself. Figure 3A) the oxygen equilibrium curves and Figure 5A) the auto-oxidation kinetics of the hHb, T-state, and R-state polyhHb’s
New paper by Palmer et al. (Ohio State U), one of the big groups working on blood substitutes. Worth following their progress! 🧪
The pilot-scale production of T- and R-state PolyhHb allows for large-scale development and modulation of their p50.
doi.org/10.1021/acs....
#HBOCs #ChemSky #AcademicSky
Paper: Spectroscopic characterization of triazine based covalent organic framework (COF) tempted changes in structure of hemoglobin (Hb). Scheme 1: schematic of the synthesis of TATF-COF. Figure 3: CD spectra of Hb in the presence of different concentrations of TATF-COF, in far (c) and near (d) UV regions. Figure 4D: TEM for conjugate of Hb with 0.03 mg/mL TATF-COF. Figure 5A: hydrodynamic size of Hb in presence of different concentrations of TATF-COF.
Interesting read 🧪:
Spectroscopic characterization of Hb in presence of TATF-COF
+ TATF-COF has regular spherical morphology (2-5 µm)
- Usage of lyophilized Hb (metHb)
+ Only slight alteration to Hb structure upon conjugation
doi.org/10.1016/j.sa...
#HBOCs #ChemSky #AcademicSky
My synthesis is not synthes-ing today, so hereby a throwback to a synthesis that did work out 🧪👩🔬
I have used these CeO2-nanoparticles both for ROS scavenging and NO releasing purposes.
doi.org/10.1021/acsa...
doi.org/10.1016/j.co...
#ChemSky #AcademicSky #QueerInSTEM #Nanozymes #HBOCs
New publication from Leticia Hosta-Rigau's group (@The3Bsgroup), using ZIF-90 instead of ZIF-8 to create a novel hemoglobin-based oxygen carrier.
#hemoglobin #HBOCs #MOF
Interesting review by Samaja et al. on the importance of assessing NO scavenging when working on hemoglobin-based oxygen carriers as blood substitutes.
#hemoglobin #HBOCs #nitricoxide
