Paillotin mutants are not sensitive to fungal toxins. Interestingly, in our hands, spz mutants also were not susceptible, differing from a previous study. However fungal toxin injection resulted in a high mortality in all lines, suggesting the preparations were virulent enough to reveal a differential sensitivity.
No in vitro activity of Paillotin was found alone or in combination with another AMP, Cecropin.
Many features of Pai suggest an #antimicrobialpeptide activity, incl. a net +ve charge, higher bacterial load in flies lacking Pai, and its upregulation by the Imd pathway.
But we found no any activity in vitro, nor evidence of another function. We refer to Pai only as a #HostDefensePeptide
5/n
1
0
1
0