Multidimensional analysis of host–virus interactions using the virus-encoded CRISPR-based direct readout system (VECOS) - Nature Protocols In the virus-encoded CRISPR-based direct readout system, single-guide RNA libraries are expressed directly from the genomes of viruses so that single-guide RNA abundance at distinct stages of the vira...

VECOS enables direct CRISPR-based investigation of host–virus interactions by embedding sgRNA libraries in viral genomes, yielding precise, multidimensional data on viral propagation dynamics.
#VirusBioinformatics #HostVirusInteractions 🔬🧬
📄 doi.org/10.1038/s415...
👤 EVBC member: Noam Stern-Ginossar