Mechanistic model for +1 frameshifting suppression. The m¹G37 tRNA modification blocks expanded codon–anticodon interactions, preserving translational fidelity.
A (belated!) highlight from an excellent collaboration with
@dunhamlab.bsky.social and #HouLabTJU.
In this Nat Commun paper, we combine smFRET and cryo-EM to show how the tRNA modification m¹G37 stabilizes the reading frame—and what happens when it’s missing.
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