The ICSA paper of the month is by @amor-lab.bsky.social & beyazlab ‼️ Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness. #ICSAPaperOfTheMonth @cshlnews.bsky.social
🔗 www.nature.com/articles/s43...
#ICSAPaperOfTheMonth. sin-lncRNA interacts with the TCA enzyme DLST to maintain metabolic balance during senescence. Depletion of sin-lncRNA causes DLST translocation to the nucleus triggering transcriptional changes that lead to metabolic reprogramming in senescence.
#ICSAPaperOfTheMonth In this Neuron paper, Graves et al find that p16 expression—particularly in microglia (the brain resident immune cells) and endothelial cells (the primary component of blood vessels)—is necessary for tau-based neurodegenerative disease in mice.
www.cell.com/neuron/fullt...
#ICSAPaperOfTheMonth Breast cancer cells resist chemotherapy by entering a transient senescent state and evading immune detection. Instead of dying, they persist and can later escape senescence to drive relapse. Disrupting this cycle could lead to new treatment strategies.
