H195Y mutation of IKZF3 identified in a mouse model of precursor B cell acute lymphoblastic leukemia impairs transcriptional repression activity and increases protein stability H195Y mutation of transcription factor IKZF3 impairs transcription repression activity and increases protein stability.

New data from Heidi Rysan, @rdekoter.bsky.social and colleagues @schulichmeddent.bsky.social - "H195Y mutation of #IKZF3 identified in a mouse model of precursor #Bcell acute lymphoblastic #Leukemia impairs transcriptional repression activity and increases protein stability"