Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology - Nature Communications Lewy body diseases exhibit notable clinical and pathological heterogeneity. Here, the authors found three distinct trajectories of Lewy body pathology that are associated with different clinicopatholo...

#MedSky🧪 #NeuroSky #ImunoSky #publichealth #MicroSky #NeuroCovid Alpha-synucleinopathies are a group of #neurodegenerativedisorders characterized by the abnormal aggregation, accumulation, & spreading of α-syn ( www.nature.com/articles/s41... ; pubs.acs.org/doi/pdf/10.1... ;

Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution - Nature Metabolism Sukka et al. delineate a metabolic pathway in macrophages that involves tryptophan uptake and metabolism to drive efferocytosis and subsequent resolution in the context of inflammation.

'We now report that efferocytosis triggers an IDO1-dependent tryptophan (Trp) metabolism pathway that promotes several key resolution processes, including the induction of pro-resolving proteins, such interleukin-10, and further enhancement of efferocytosis.'
#Immunology #Imunosky