We will be hosting a webinar to together with
@mitotalks.bsky.social to highlight research in our recent Special Issue: Cell Biology of Mitochondria.
Register here: focalplane.biologists.com/2025/06/09/m...
Explore our ToC: journals.biologists.com/jcs/issue/13...
#JCSMitoSI
Gordon Freedman from @mitoworld.bsky.social chats with JCS Executive Editor @seemagrewal.bsky.social about our special issue on ‘Cell Biology of Mitochondria’.
#JCSMitoSI #Mitochondria
mitoworld.org/special-issu...
Heidi McBride
In our Special Issue: Cell Biology of Mitochondria we interview Guest Editor Heidi McBride @mitodynamics.bsky.social Heidi discusses her career path, the past, present & future of #mitochondria research & her role as guest editor at JCS.
journals.biologists.com/jcs/article/...
#JCSMitoSI
Soumyajit Mukherjee, Shreya Das, Arunima Sengupta, Alok Ghosh and colleagues find that pyruvate plus uridine augments mitochondrial respiration & prevents cardiac hypertrophy in zebrafish & H9c2 cells. #JCSMitoSI #JCSSnapshots
journals.biologists.com/jcs/article/...
youtu.be/PUqjJQu4oSA?...
Screenshot of article titled,’ A lipid in transit – the journey of cholesterol into the heart of mitochondrial research’ published in Journal of Cell Science’s Special Issue: Cell Biology of Mitochondria.
In their Perspective, Thomas Simmen & Luca Pellegrini propose a model of cholesterol trafficking into & out of #mitochondria via phospholipids at mitochondria-associated membranes, challenging the traditional view of protein-driven transport.
journals.biologists.com/jcs/article/...
#JCSMitoSI
Dikaia Tsagkari, Maria Markaki and Nektarios Tavernarakis discover that NHR-85 modulates mitochondrial and lipid homeostasis to protect against α-synuclein aggregation.
journals.biologists.com/jcs/article/...
youtu.be/UGNOAsFFDYU?...
#JCSMitoSI #JCSSnapshot
We are delighted to launch ‘JCS snapshots’, in collaboration with @focalplane.bsky.social. In these short talks, authors share the key findings of their research. Our first snapshots are from our Special Issue: Cell Biology of Mitochondria. #JCSMitoSI
focalplane.biologists.com/2025/05/21/i...
Samantha Lewis
Our latest ‘Cell Scientist to Watch’ is Samantha Lewis. We caught up with Samantha to discuss her career path, the challenges for working on the ‘neglected’ mitochondrial genome and the exciting new frontiers in mitochondrial research.
journals.biologists.com/jcs/article/...
#JCSMitoSI
Figure showing that transposed SDHB rescues imCC phenotypes.
Fatimah Al Khazal, Leili Rahimi, James Maher and colleagues find that oncogenic succinate accumulation can be reduced by restoration of succinate dehydrogenase activity in cultured adrenal cells.
journals.biologists.com/jcs/article/...
#OpenAccess #JCSMitoSI #Mitochondria
Figure showing organellar proteome and morphology changes upon OCIAD1 KO.
Following lipidomic and proteomic analyses, Vanessa Linke @massspecvanili.bsky.social Agnieszka Chacinska and colleagues identify a role for OCIAD1 at the mitochondria-peroxisome intersection balancing lipid metabolism.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
JCS poster ‘Mitochondria–membranous organelle contacts at a glance’ Antigoni Diokmetzidou, Luca Scorrano
In their Cell Science at a Glance article, Antigoni Diokmetzidou and Luca Scorrano summarise the mitochondrial contacts characterised in mammals, the molecular mechanisms underlying their formation, and their principal functions.
journals.biologists.com/jcs/article/...
#JCSMitoSI #OpenAccess
Quality control of un-imported mitochondrial proteins at a glance Megan Balzarini, John Kim, Hilla Weidberg
In their Cell Science at a Glance article, Megan Balzarini, John Kim and Hilla Weidberg summarise the fate of un-imported mitochondrial proteins and the compartment-specific quality control pathways that regulate them.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
Hye Jin Hwang, Kelsey Sheard and Rachel Cox find that Drosophila Clu ribonucleoprotein particle dynamics rely on the availability of functional Clu and translating ribosomes.
journals.biologists.com/jcs/article/...
#OpenAccess #JCSMitoSI #Mitochondria
- Mitochondria – the CEO of the cell
Reviews on:
- The role of mitochondrial mRNA translation in cellular communication
- Origin & evolution of mitochondrial IM composition
- Mitochondrial fission – changing perspectives for future progress
journals.biologists.com/jcs/issue/13...
#JCSMitoSI
Journal of Cell Science cover Special Issue on Cell Biology of Mitochondria Guest Editors: Ana J. Garcia-Saez and Heidi McBride Image of mitochondria (magenta) and DNA (cyan) in glioblastoma cells
Our Special Issue: Cell Biology of Mitochondria is complete.
Explore our ToC: journals.biologists.com/jcs/issue/13...
Our cover image highlights mitochondria (magenta) and DNA (cyan) in glioblastoma cells from Buckley et al.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
Figure showing the human TOM interactome.
Metin Özdemir, Sven Dennerlein and colleagues define a TOM complex interactome, revealing diverse interaction partners that include the new interactors MAPL, ATAD1 and TRABD.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
Gustavo Gavrel Pacheco
Read more about this research in our ‘First person’ interview with Gustavo Gavrel Pacheco: journals.biologists.com/jcs/article/...
#JCSMitoSI
Figure showing that MMP in mesendoderm cells is dependent on integrin activation state and signalling.
Gustavo Pacheco, Douglas DeSimone and colleagues discover that mitochondrial membrane potential is spatially regulated in collectively migrating tissue by integrin adhesion and signalling in leader row cells.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
Figure showing that ERMES disruption influences melanin and capsule production.
Deepika Kumari, Ritu Pasrija and colleagues find that ER–mitochondria encounter structure (ERMES) connections determine drug sensitivity and virulence of Cryptococcus neoformans.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
Working model of Mix17 biogenesis
Moritz Resch, Max Harner and colleagues @bmc-lmu.bsky.social find that the Mia40 substrate Mix17 exposes its N-terminus to the cytosolic side of the mitochondrial outer membrane.
journals.biologists.com/jcs/article/...
#JCSMitoSI #OpenAccess #ReadandPublish
Cell-to-mitochondria communication by regulating the translation of NEM mRNAs. The translation of NEM mRNAs serves as a crucial communication node, integrating incoming signals and output cellular responses. Translation is regulated by binding to RBPs, which respond to incoming cellular signals (e.g. mTORC1, AMPK and insulin) and control translation in both time and space. In turn, ribosomal stress caused by stalled ribosomes transmits information about mitochondrial status and initiates stress responses. Created in BioRender by Rugarli, E., 2025. https://BioRender.com/d27y662. This figure was sublicensed under CC-BY 4.0 terms.
In their Review, Eleonora Zilio, Elena Rugarli and colleagues @cecad.bsky.social @crc1218.bsky.social discuss the role of mitochondrial mRNA translation in cellular communication.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
Figure showing that deletion of Miro1 leads to perinuclear mitochondrial clustering and increased networking without changes to matrix H2O2 levels.
Nathaniel Shannon, Brian Cunniff and colleagues discover that Miro1 expression alters global gene expression, ERK1/2 phosphorylation, oxidation and cell cycle progression.
journals.biologists.com/jcs/article/...
#JCSMitoSI #mitochondria
Figure showing that ischemia and ischemia/reperfusion simulation induces HIF1α translocation and cell injury in EHTs.
Mireia Nàger, Asa Birgisdottir and colleagues find that mitophagy is induced in human engineered heart tissue after simulated ischemia and reperfusion.
journals.biologists.com/jcs/article/...
#JCSMitoSI #OpenAccess #ReadandPublish
Bacterial ICMs exhibit internal invaginations that resemble eukaryotic cristae. (A)TEM images showing tubular cristae-like ICM compartments in free-living Desulfobacterota, and similar cristae-like ICM tubules in Desulfovibrio carbinolicus strains. The eukaryotic model organism S. cerevisiae exhibits tubular cristae structures, whereas the commonly used HEK293 cell line exhibits predominantly lamellar cristae structures. Scale bars: 500 nm. (B) Eukaryotic mitochondria tend to exhibit lamellar, tubular or discoidal cristae morphology, whereas orders of the class alphaproteobacteria exhibit a range of ICM morphologies. Lamellar-like ICMs, which exhibit parallel cytoplasmic protrusions that do not contact the inner membrane, are commonly observed in nitrogen-fixing and several methanotrophic alphaproteobacteria. (C) This simplified and non-exhaustive cladogram indicates the two domains of life – bacteria and archaea – with proto-mitochondria emerging in early alphaproteobacteria. Eukaryogenesis is marked by the horizontal transfer (red dotted arrow) from Bacteria to Hordarchaeales in Asgard archaea. §, †, #, * and ‡ connect species listed in B to their respective clades in C.
Kailash Venkatraman, Nicolas-Frédéric Lipp & @ibudin.bsky.social examine the similarities between prokaryotic intracytoplasmic membranes & mitochondrial IMs, & discuss whether cristae evolution has driven specialisation of the #mito lipidome.
journals.biologists.com/jcs/article/...
#JCSMitoSI
Schematic showing that mitochondria can be understood as the ‘Chief Executive Organelle’ of the cell! Mitochondria play key roles in determining cell fate, including regulation of cell division, stem cell differentiation, senescence and cell death, akin to decisions a CEO makes about the growth, diversification or closure of a company. Mitochondria also control key cell resources, including ATP and a variety of other metabolites. Furthermore, mitochondria act as signalling hubs, mediating both intracellular and intercellular signalling, much like communication lines within and between organizations, and regulate innate immune pathways that act as the security system of the cell. Given the many instructive roles mitochondria carry out, we argue that they should be considered the CEO of the cell. This figure was partly generated using Servier Medical Art, provided by Servier, licensed under a CC-BY 3.0 Unported license.
In their Opinion article, Laurie Lee-Glover, Martin Picard and Timothy Shutt @mitomorph.bsky.social argue that mitochondria should be considered as the ‘Chief Executive Organelle’ – the CEO – of the cell. #JCSMitoSI #Mitochondria
journals.biologists.com/jcs/article/...
Figure showing that mitochondrial subpopulations proximal to endosomes and lipid droplets have similar proteomes, but both are significantly different from an average mitochondrial proteome.
In their Tools & Resources article, Corey Cunningham @cnfxc.bsky.social Jared Rutter @rutterlab.bsky.social @uofubiochem.bsky.social & team present their dual-purification system to isolate mitochondrial subpopulations.
journals.biologists.com/jcs/article/...
#JCSMitoSI #OpenAccess #Mitochondria
IMM fission. (A) Negative-stain EM micrograph of a mitochondrion from a HeLa cell, showing prominent inner membrane folds (cristae) as well as the non-cristae regions of the IMM, the inner boundary membrane (IBM). The cristae junction is the interface of the IBM and the cristae infolding. IMS, intermembrane space. Note the small diameter of the cristae lumen (typically ∼10 nm). Scale bar: 200 nm. Image taken by Radu Stan in the Dartmouth College Electron Microscopy Facility. (B) Schematic illustration of possible consequences of uncoordinated IMM–OMM fission. This could lead to cytosolic leakage of IMS or cristae lumenal components (e.g. cytochrome c) or matrix components (e.g. mtDNA) and subsequent activation of apoptosis or inflammatory pathways, respectively. Please note that these potential consequences are the authors' speculation and that mechanisms of actin IMM fission and coordination between IMM and OMM fission remain unclear. Created in BioRender by Kamerkar, S., 2025. https://BioRender.com/e48m132. This panel was sublicensed under CC-BY 4.0 terms.
In their Review, Sukrut Kamerkar, Ao Liu and Henry Higgs discuss how individual aspects of mitochondrial fission might be integrated to give a more holistic understanding.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria
Samruddhi Shembekar
Read more about this research in our ‘First person’ interview with Samruddhi Shembekar: journals.biologists.com/jcs/article/...
#JCSMitoSI
Ultrastructural analysis of mitochondria in various Miro DKO rescue cells.
Samruddhi Shembekar, Martin Bähler and colleagues interrogate the regulation of mitochondrial cristae organisation by Myo19, Miro1 and Miro2, and metaxin 3.
journals.biologists.com/jcs/article/...
#JCSMitoSI #Mitochondria #OpenAccess #ReadandPublish
Tom MacVicar
Our ‘Cell Scientist to Watch’ interview is with Tom MacVicar. We caught up with Tom to discuss his career path, his advice on establishing research independence and why it’s an exciting time to be a mitochondrial biologist.
#JCSMitoSI
journals.biologists.com/jcs/article/...
