Graphical Abstract: This novel fasting-based disposition index (SPINA-DI) is defined as the product of insulin receptor gain (SPINA-GR) multiplied by beta-cell function (SPINA-GBeta). SPINA-DI may be reduced due to insulin resistance with insufficient dynamical compensation of beta-cell mass (red horizontal arrow) or due to primary beta-cell failure (red vertical arrow). SPINA-DI was validated in three cohorts. It had advantages in validity, reliability and diagnostic power compared to established criteria.
Sample title page of the Journal of Diabetes
I am honoured to see our paper "A novel simple disposition index (SPINA-DI) from fasting insulin and glucose concentration as a robust measure of carbohydrate homeostasis" among the "most impactful papers" of the #Journal_of_Diabetes.
onlinelibrary.wiley.com/doi/toc/10.1...
doi.org/10.1111/1753...