#KaylaSprenger

Synergistic reduction in interfacial flexibility of TREM2R47H and ApoE4 may underlie AD pathology BACKGROUND The strongest genetic drivers of late-onset Alzheimer's disease (AD) are apolipoprotein E4 (ApoE4) and TREM2R47H. Despite their critical roles, the mechanisms underlying their interaction.....

Trem2 is more flexible than we thought, and likes to bind to ApoE4! Congrats #EmmaLietzke and #KaylaSprenger on your work! It's a privilege to work with you!! @cuendocrinology.bsky.social alz-journals.onlinelibrary.wiley.com/doi/10.1002/...