In a patient who is IV drug user and IF showing C3 only staining, what is your diagnosis?
#DiagnoseThis #nephtwitter #pathtwitter #renal #kidneypath
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#KidneyPath
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A sample from the pathology teaching slide set on IgA Nephropathy, jointly prepared by Arkana Laboratories and @goKDIGO. http://KDIGO.org/guidelines/gd/
#KDIGO #pathology #renal #kidneypath
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Here is today’s #eyeSCANdy! Scanning EM of a normal glomerulus showing a glomerular capillary loop with interdigitating podocyte foot processes.
Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath
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Some patients with membranous glomerulopathy also have associated focal segmental glomerulosclerosis (FSGS) lesions.
#TeachingPoints #kidneypath #renal #pathology
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This is an IgG IF viewed under both fluorescent and polarized light from a patient with AKI following endovascular procedure. What is your diagnosis?
#DiagnoseThis #nephtwitter #pathtwitter #renal #kidneypath
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A sample from the pathology teaching slide set on Membranous Glomerulopathy, jointly prepared by Arkana Laboratories and @goKDIGO. http://KDIGO.org/guidelines/gd/
#KDIGO #pathology #renal #kidneypath
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Here is today’s #eyeSCANdy! Scanning EM of a normal glomerulus showing a glomerular capillary loop with interdigitating podocyte foot processes.
Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath
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Commentary
Pathologic diagnosis incorporating molecular monitoring highlights new pathophysiological mechanisms in kidney xenotransplantation
doi.org/10.1016/j.kint.2025.12.021
Original Article: doi.org/10.1016/j.kint.2025.11.018
#MedSky #NephSky #kidneypath #renalpath #transplantation
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This is a CMV IHC stain, showing CMV positive cells within glomeruli. CMV viral load was four million copies/ml, and bilateral CMV pneumonia was diagnosed.
#renalpath #kidneypath #pathology #renal
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As published decades ago by Bonsib et al. (see reference), fluorescence microscopy of eosin-stained frozen section slides can be a valuable tool in providing diagnostic clues in kidney biopsies.
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32 yo renal transplant recipient with AKI and pneumonia. A recent biopsy had shown borderline changes for TCMR and the patient received pulse steroids.
#DiagnoseThis #nephtwitter #pathtwitter #renal #kidneypath
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Sometimes the giant cells in granulomatous inflammation are truly giant!
#nephsky #pathsky #renal #kidneypath
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A sample from the pathology teaching slide set on Lupus Nephritis and Thrombotic Microangiopathy (TMA), jointly prepared by Arkana Laboratories and @goKDIGO. http://KDIGO.org/guidelines/gd/
#KDIGO #pathology #renal #kidneypath
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Here is today’s #eyeSCANdy! Scanning EM of a normal glomerulus showing a glomerular capillary loop with interdigitating podocyte foot processes.
Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath
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There were also mesangial IgA deposits (Figure 3), which likely explain the patient's hematuria and proteinuria, since there was very little glomerular amyloid (Figure 4).
#renalpath #kidneypath #pathology #renal #pathsky
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The stain is a Congo Red viewed under fluorescent light with a red filter. It highlights interstitial amyloid deposits, which is the predominant pattern of deposition in LECT2 amyloidosis (confirmed by IHC stain, Figure 2).
#renalpath #kidneypath #pathology #renal #pathsky
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1/ This allograft biopsy shows the characteristic features of adenovirus infection.
#TeachingPoints #kidneypath #renal #pathology
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This is the biopsy of a 62yo Hispanic female with hematuria and proteinuria. What is this stain and what is the diagnosis?
#DiagnoseThis #nephtwitter #pathtwitter #renal #kidneypath
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A sample from the pathology teaching slide set on Lupus Nephritis: Maintenance Therapy for Class Ill and IV LN, jointly prepared by Arkana Laboratories and @goKDIGO. http://KDIGO.org/guidelines/gd/
#KDIGO #pathology #renal #kidneypath
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Here is today’s #eyeSCANdy! Scanning EM of a normal glomerulus showing a glomerular capillary loop with interdigitating podocyte foot processes.
Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath
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1/ This electron microscopy shows marked GBM abnormalities, consistent with Alport's Syndrome (AS). The patient had genetic testing, which confirmed a COL4A3 mutation.
#renalpath #kidneypath #pathology #renal
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2/ Predominantly subepithelial deposits, in contrast, would be expected in most cases of membranous glomerulopathy.
#TeachingPoints #kidneypath #renal #pathology
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In a 23yo M with proteinuria, hematuria and CKD, what is your diagnosis?
#DiagnoseThis #nephsky #pathsky #renal #kidneypath
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Here is today’s #eyeSCANdy! Acellular scanning EM of a normal glomerular tuft showing the subpodcocytic capillary loop basement membranes following removal of the podocytes.
Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath
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A sample from the pathology teaching slide set on Immunoglobulin and Complement-Mediated Glomerular Diseases with an MPGN Pattern of Injury, jointly prepared by Arkana Laboratories and @goKDIGO. http://KDIGO.org/guidelines/gd/
#KDIGO #pathology #renal #kidneypath
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1/ The biopsy shows collapsing glomerulopathy, for which the differential diagnosis in a transplant recipient includes ischemia, calcineurin inhibitor nephrotoxicity, CMV infection, thrombotic microangiopathy, and donor-derived APOL1-associated nephropathy.
#renalpath #kidneypath
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This is the biopsy from a 41yo Middle Eastern female who received a renal transplant a few years prior and presents with AKI. What is your diagnosis?
#DiagnoseThis #nephsky #pathsky #renal #kidneypath
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Here is today’s #eyeSCANdy! Acellular scanning EM of a normal glomerular tuft showing the subpodcocytic capillary loop basement membranes following removal of the podocytes.
Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath
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A sample from the pathology teaching slide set on Immunoglobulin and Complement-mediated Glomerular Diseases with an MPGN Pattern of Injury, jointly prepared by Arkana Laboratories and @goKDIGO. http://KDIGO.org/guidelines/gd/
#KDIGO #pathology #renal #kidneypath
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