The study suggests doctors should test for HTRA1 in older patients when standard tests don't find a cause, since identifying the actual problem helps determine the right treatment. #renalpath #nephsky #pathsky
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#renalpath
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This new approach more accurately reflects what we know today. Better clarity on who's truly at risk means better decisions for patients and matters for clinical trial design and future treatments currently in development. #renalpath
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Transplant bx for renal dysfunction in a patient with shortness of breath. Granulomatous tubulointerstitial nephritis. AFB stain +. Sputum + for TB. Good sample key for making the diagnosis. 2 rounds of AFB stain to find the organism. #renalpath #pathksy #nephsky
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1/ The image shows global endocapillary hypercellularity with numerous neutrophils (exsudative glomerulonephritis). The patient was found to have tricuspid valve endocarditis.
#renalpath #kidneypath #pathology #renal
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Bx for pt with AKI and nephrotic range proteinuria. Hx of IV drug abuse (with skin popping), and chronic staph infections. AA amyloidosis was the unsurprising finding. #renalpath #pathsky #nephsky
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Bx for AKI in a pt on checkpoint inhibitor: neutrophil rich tubulointerstitial nephritis. We would usually think pyelonephritis, high risk neutrophil rich variants of CKI inhibitor AIN have been characterized. pubmed.ncbi.nlm.nih.gov/41727781/ #renalpath #pathsky #nephsky
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Classic powdery electron dense deposits along GBMs, TBMS, and in vascular walls by EM in this case of light chain deposition disease. #renalpath #pathsky #nephsky
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Don't confuse these for crystals. Limiting membrane of peroxisomes in proximal tubules. Normal tubular structure. Mimic of light chain proximal tubulopathy. #renalpath #pathsky #nephsky
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Commentary
Pathologic diagnosis incorporating molecular monitoring highlights new pathophysiological mechanisms in kidney xenotransplantation
doi.org/10.1016/j.kint.2025.12.021
Original Article: doi.org/10.1016/j.kint.2025.11.018
#MedSky #NephSky #kidneypath #renalpath #transplantation
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This is a CMV IHC stain, showing CMV positive cells within glomeruli. CMV viral load was four million copies/ml, and bilateral CMV pneumonia was diagnosed.
#renalpath #kidneypath #pathology #renal
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Figure 1 Light and electron microscopy reveal epithelial cell vacuolation in acute tubular injury. (a) Light microscopy shows focal acute tubular injury at the corticomedullary junction, with significant swelling of tubular epithelial cells caused by optically transparent vacuoles. Hematoxylin and eosin staining. Bar = 50 μm. (b) The vacuoles contain periodic acid–Schiff–positive material. Bar = 50 μm. (c) Electron microscopy of paraffin-fixed tissue reveals the outline of tubular epithelial cell membranes, partial cell nuclei, and degenerated organelles, with obvious intracellular cavitation. Bar = 10 μm. To optimize viewing of this image, please see the online version of this article at www.kidney-international.org.
The Armanni-Ebstein (not Epstein😅) lesion in a nondiabetic patient
The glycosuria from flozination can cause these, very interesting phenomenon
www.kidney-international.org/article/S008... in Kidney International
#RenalPath
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Registration is still open for the RPS Satellite Meeting and Reception at USCAP 2026 in San Antonio, TX
Drug Therapies: footprints on the kidney
👉https://renalpathsoc.org/event-6567896
RPS RECEPTION AND AWARDS
👉https://renalpathsoc.org/event-6568023
#renalpath #USCAP2026
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There were also mesangial IgA deposits (Figure 3), which likely explain the patient's hematuria and proteinuria, since there was very little glomerular amyloid (Figure 4).
#renalpath #kidneypath #pathology #renal #pathsky
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The stain is a Congo Red viewed under fluorescent light with a red filter. It highlights interstitial amyloid deposits, which is the predominant pattern of deposition in LECT2 amyloidosis (confirmed by IHC stain, Figure 2).
#renalpath #kidneypath #pathology #renal #pathsky
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Autolysis versus ATN in an autopsy specimen. Autolytic tubules show detachment of epithelial cells from tubular BM and seem to fall off into the lumen (yellow circle). Rest of tubules with ATN: epithelial cells on the BM but thin + loss of brush borders. #renalpath #pathsky
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1/ This electron microscopy shows marked GBM abnormalities, consistent with Alport's Syndrome (AS). The patient had genetic testing, which confirmed a COL4A3 mutation.
#renalpath #kidneypath #pathology #renal
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Allograft biopsy for AKI after belatacept conversion. Yikes! Acute cellular rejection grade III with necrotizing arteritis. #renalpath #pathsky #nephsky
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We're excited to share a new research publication from @aaronstorey.bsky.social, @glombandit.bsky.social, and Dr. Chris Larsen titled, "Proteomic Profiling of Complement Components in Glomerular Disease."
Read here: https://pubmed.ncbi.nlm.nih.gov/41720186/
#ArkanaResearch #RenalPath #RenalResearch
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Some large KW nodules in this case of diabetic nephropathy. Unfortunately a common occurrence in my biopsy practice. #renalpath #pathsky #nephsky
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Another chronic glomerulopathy case. EM stage IV of IV resorbed deposits in a pt with PLA2R+ Membranous nephropathy with persistent proteinuria. #renalpath #pathsky #nephsky
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1/ The biopsy shows collapsing glomerulopathy, for which the differential diagnosis in a transplant recipient includes ischemia, calcineurin inhibitor nephrotoxicity, CMV infection, thrombotic microangiopathy, and donor-derived APOL1-associated nephropathy.
#renalpath #kidneypath
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Figure 1 Hematoxylin andeosin–stainedrenal biopsy(original magnification ×40) of the patient showingtubulointerstitial nephritis, characterized by a mononuclear inflammatory infiltrate with clusters ofmacrophages containing round intracytoplasmic structures (highlighted by the black circle). The Grocott-stained specimen (see Supplementary Figure S1) revealed intracytoplasmic round structures consistent with Histoplasma capsulatum yeasts. These histologic features supported the diagnosis of interstitial nephritis by Histoplasma spp. (see Supplementary Figure S1 for the differential diagnosis discussion).
Supplementary Figure S1. Grocott-stained specimen demonstrating intracytoplasmic round structures consistent with Histoplasma capsulatum yeasts (indicated by the red arrow). The differential diagnosis with other fungi (such as Cryptococcus, Candida, Blastomyces, and Paracoccidioides) and other intracellular pathogens (such as Toxoplasma, Leishmania, and Trypanosoma) was made based on the following histopathologic features: small size (2–5 μm), round shape, homogeneous intracellular distribution, silver positivity, absence of kinetoplasts, and negative mucicarmine staining—all of which supported the diagnosis of histoplasmosis.
Acute interstitial nephritis from ....histoplasma
www.kidney-international.org/article/S008...
@kidneyint.bsky.social
#NephSky #RenalPath
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Recent bxs are so important for clinical trial enrolment. Bx in pt with hx of lupus nephritis (IV+V) with worsening proteinuria. Bx for trial enrollment. Chronic changes only, 0 activity, resorbed deposits by EM, min IF staining. #nephsky #renalpath #Pathsky
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USCAP 2026 Lunch Presentation
Discover Important Updates in C3G
Presenter: Anthony Chang, MD
University of Chicago Medical Center
Sunday, March 22nd, 12 - 1 PM CT
No registration required
Lunch provided
@uscap.org @changucanspare.bsky.social
#USCAP2026 #renalpath #pathsky
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Bx in older F pt for subnephrotic proteinuria reveals numerous myelin figures in podocytes. Concern for Fabry + other genetic diseases. Subsequently learned the pt was on long term to Plaquenil. Genetics pending, but may all be HCQ tox. #renalpath #pathsky #nephsky
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RPS Satellite meeting - Hybrid
Drug Therapies: Footprints on the Kidney
Sunday, March 22nd, 1 - 4 PM CT
In-person: registration available until March 16
Virtual: registration available until March 21
renalpathsoc.org/event-6567896
@uscap.org
#USCAP #renalpath #pathsky #nephsky #nephrology
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The PAS-stain picture depicts gray and basophilic amorphous material within glomerular capillaries, consistent with polymer emboli. The patient had undergone renal transplant artery angioplasty a few months earlier.
Reference: www.sciencedirect.com/science/arti...
#renalpath #pathology
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Amyloid spicules, so-called "eyelashes", as they lay down perpendicularly along the glomerular basement membrane. #UnderTheScope #renalpath #pathsky
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