Transplant bx for renal dysfunction in a patient with shortness of breath. Granulomatous tubulointerstitial nephritis. AFB stain +. Sputum + for TB. Good sample key for making the diagnosis. 2 rounds of AFB stain to find the organism. #renalpath #pathksy #nephsky
Bx for progressive CKD in a pt with CML, in remission. Limited biopsy with prominent debris filled proximal tubule lysosomes + for lysozyme (no evidence for light chain restriction (F/P) or chromogranin). Suspicious for lysozyme nephropathy. #renalpath #pathksy #nephsky
Interestingly this patient also had IgM dominant immune complex deposition. IC-GN reported with higher frequency with PDG. In my opinion, probably non-specific related to PDG glomerular injury (especially IgM). pubmed.ncbi.nlm.nih.gov/24579775/ #renalpath #nephsky #pathksy
Txp biopsy with persistent heavy proteinuria since early post-transplant period in a recipient of a peds split en-bloc graft. Pediatric donor glomerulopathy with segmental sclerosis, mesangial hypercellularity, and atypical GBM remodeling. #renalpath #nephsky #pathksy
A glomerulus touched by lupus. Example of finger print type deposits in this patient with lupus nephritis. #renalpath #pathksy #nephsky
