#LEOFondet

Peptide Backbone Cleavage and trans-Amidation via Thioester-to-Imide Acyl Transfer Cysteine thioesters are involved in a myriad of cen-tral biological transformations because of their unique reactivity. Despite their well-studied proper-ties, we discovered an unexpected trans-amidat...

In a new preprint @chemrxiv.bsky.social, work from @bgless.bsky.social and Sabrina Schmied investigate the mechanism of a rearrangement that can lead to peptide/protein backbone cleavage.

Thanks to #LEOFondet for funding the project that led to this discovery.

chemrxiv.org/engage/chemr...