This paper shows a microvascularized liver model with hepatocytes, stellate cells, and a self-organized perfusable endothelial plexus - native-like structure and HTS-ready robustness (excellent Z’). Big step for #MASH & anti-fibrotic screening research. Read here: shorturl.at/gOskI
#LiverOnAChip

Frontiers | Alternatives to animal-derived extracellular matrix hydrogels? An explorative study with HepaRG cells in animal-free hydrogels under static and dynamic culture conditions New approach methodologies (NAMs) aim for animal-free chemical risk assessments. However, many in vitro NAM models still depend heavily on Matrigel and colla...

Great to see this new paper from Katharina Nitsche and colleagues exploring animal-free ECMs for liver models. PeptiMatrix performed strongly under flow, showing CYP3A4 inducibility at 7.5 mg/mL.

Read more 👉 www.frontiersin.org/journals/tox...

#PeptiMatrix #NAMs #3DCellCulture #LiverOnAChip

🎓 Congrats to Dr. Flavio Bonanini on his PhD defense! His work at MIMETAS on liver MPS brings us closer to better, animal-free drug testing for diseases like diabetes & liver fibrosis. 🧪🩺

Watch his webinar: lnkd.in/eqdEFYaP
#PhDDefense #LiverOnAChip #MPS #DrugDevelopment #OrgansOnChips