Anti-atherosclerotic #LockedNucleicAcid targeting miR-206-3p-CXCR4 mRNA binding site

⏫CXCR4 in EC/SMC/B Cell

⏫EC proliferation+barrier->⏬LDL retention⏬leukocyte infiltr

⏫B cell production of IgM

No effects on plaque SMC content/systemic inflamm

#SciTransMed 2023
www.science.org/doi/10.1126/...