Global deletion of Pcif1 decreases bone mass. Top left: Representative Micro-CT images of femurs from 6-week-old male Pcif1−/− knockout mice and Pcif1+/+ littermates. Scale bar, 200 μm. Bottom left: Representative images of Von Kossa staining of undecalcified femoral sections. Scale bar, 500 μm. Right: Schematic diagram of the manuscript created using selected icons from BioRender.

m6A RNA mods play a role in #bone homeostasis, but what about m6Am? This study shows that the PCIF1 m6Am #methyltransferase supports bone mass maintenance by stabilizing Wnt pathway transcripts & promoting #osteogenic differentiation of mesenchymal stem cells @plosbiology.org 🧪 plos.io/4tC9lPO

Global deletion of Pcif1 decreases bone mass. Top left: Representative Micro-CT images of femurs from 6-week-old male Pcif1−/− knockout mice and Pcif1+/+ littermates. Scale bar, 200 μm. Bottom left: Representative images of Von Kossa staining of undecalcified femoral sections. Scale bar, 500 μm. Right: Schematic diagram of the manuscript created using selected icons from BioRender.

m6A RNA mods play a role in #bone homeostasis, but what about m6Am? This study shows that the PCIF1 m6Am #methyltransferase supports bone mass maintenance by stabilizing Wnt pathway transcripts & promoting #osteogenic differentiation of mesenchymal stem cells @plosbiology.org 🧪 plos.io/4tC9lPO

Global deletion of Pcif1 decreases bone mass. Top left: Representative Micro-CT images of femurs from 6-week-old male Pcif1−/− knockout mice and Pcif1+/+ littermates. Scale bar, 200 μm. Bottom left: Representative images of Von Kossa staining of undecalcified femoral sections. Scale bar, 500 μm. Right: Schematic diagram of the manuscript created using selected icons from BioRender.

m6A RNA mods play a role in #bone homeostasis, but what about m6Am? This study shows that the PCIF1 m6Am #methyltransferase supports bone mass maintenance by stabilizing Wnt pathway transcripts & promoting #osteogenic differentiation of mesenchymal stem cells @plosbiology.org 🧪 plos.io/4tC9lPO

New research in #RESInsectMolecBio

Ame-miR-2161 affects the survival and development of #honeybee larvae through the #JuvenileHormone acid #methyltransferase gene
doi.org/10.1111/imb.70009

#Apis #JH #Jhamt #miRNA
@sassanasgari.bsky.social @gulianusslab.bsky.social @wiley.com

BREX system's unique DNA recognition mechanism enhances bacterial antiviral defense Bacteriophages, the most abundant life form on Earth, infect bacterial cells and influence the structure of the microbial community. To fend off phage attacks, bacteria have evolved their own defense ...

#BREX system's unique #DNA_recognition mechanism enhances #bacterial #antiviral defense.

#bacteriophages #methyltransferase

phys.org/news/2025-03...

#methyltransferase #gerontology #NCDs #SDGs #cancer #pediatrics

Benzene
increases the risk of leukemia
through its toxic effects on bone marrow cells.

Aberrant METTL14 gene expression
contributes to malignant transformation of
benzene-exposed myeloid cells
www.sciencedirect.com/science/arti...

PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Learn about the unusual architecture & unique coupling principle of B12-dependent #methyltransferase complex of #methanogenesis in this paper in #PNAS co-authored by our group leader Tristan Wagner
A great #MaxPlanck-cooperation!
www.pnas.org/doi/10.1073/...
www.mpi-bremen.de/en/Max-Planc...