Exploring infection biology with mass spectrometry-based proteomics Abstract. Investigating host-pathogen interactions at the molecular level is critical for understanding infection mechanisms and identifying potential ther

Exploring infection biology with mass spectrometry-based proteomics #MolOmics academic.oup.com/molecular-om...

Urine metabolomics for seronegative rheumatoid arthritis: an exploratory dual-platform analysis Abstract. Seronegative rheumatoid arthritis (negRA) is difficult to diagnose due to the absence of rheumatoid factor and anticitrullinated peptide antibodi

Urine metabolomics for seronegative rheumatoid arthritis: an exploratory dual-platform analysis #MolOmics #MassSpec academic.oup.com/molecular-om...

Identification of metabolomic signatures of diabetic kidney disease in urine and plasma using untargeted gas chromatography–mass spectrometry Abstract. Diabetic kidney disease (DKD) is a complication of diabetes and the leading cause of kidney failure among diabetic patients. Unfortunately, it is

Identification of metabolomic signatures of diabetic kidney disease in urine and plasma using untargeted gas chromatography–mass spectrometry #MolOmics academic.oup.com/molecular-om...

Urinary Metabolomics Identifies Lactate as a Biomarker for Bladder Cancer Detection and Progression Abstract. Bladder cancer (BC) is the ninth most prevalent malignancy worldwide. It remains a significant clinical burden due to high recurrence rates and t

Urinary Metabolomics Identifies Lactate as a Biomarker for Bladder Cancer Detection and Progression #MolOmics #MassSpec academic.oup.com/molecular-om...

A Mass Spectrometry-Based Approach Identifies a Putative Plasma Protein Biomarker Signature for Early Diabetic Kidney Disease Diagnosis Abstract. Diabetic kidney disease (DKD) is the leading cause of kidney failure among diabetic patients. At the time of clinical diagnosis, kidney function

Mass Spectrometry-Based Approach Identifies a Putative Plasma Protein Biomarker Signature for Early Diabetic Kidney Disease Diagnosis #MolOmics academic.oup.com/molecular-om...

Mapping the Helichrysum metabolome: uncovering species-specific chemistry through an AI-guided LC-MS/MS workflow Helichrysum species, of which 35% are native to South Africa, are renowned for their diverse medicinal properties, yet their chemical composition remains largely unexplored. As such, continuous effort...

Mapping the Helichrysum metabolome: uncovering species-specific chemistry through an AI-guided LC-MS/MS workflow #MolOmics pubs.rsc.org/en/content/a...

Global spinal cord peptidome profiling in response to osteoarthritis in rats Osteoarthritis (OA) is a complex and increasingly prevalent condition, affecting an estimated 600 million people worldwide and significantly reducing quality of life. Understanding OA as both an infla...

Global spinal cord peptidome profiling in response to osteoarthritis in rats #MolOmics #MassSpec pubs.rsc.org/en/content/a...

Mass spectrometry-based profiling of phosphoinositide: advances, challenges, and future directions Phosphoinositides (PIPs), the phosphorylated derivatives of phosphatidylinositol (PI), are low-abundance yet critical components of eukaryotic membranes. They play pivotal roles in a wide array of cel...

Mass spectrometry-based profiling of phosphoinositide: advances, challenges, and future directions #MolOmics pubs.rsc.org/en/content/a...

MALDI mass spectrometry imaging in plant and food lipidomics: advances, challenges, and future perspectives Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has established itself as a powerful analytical technique for spatially resolved lipidomics, offering unique insights ...

MALDI mass spectrometry imaging in plant and food lipidomics: advances, challenges, and future perspectives #MolOmics pubs.rsc.org/en/content/a...

Comparative glycomic analysis of hawk (Rupornis magnirostris), caiman (Caiman latirostris) and sea turtle (Caretta caretta) tear films Glycans are recognized as biomarkers and therapeutic targets. However, these molecules remain a critical blind spot in understanding post-translational modifications, particularly in vertebrate specie...

Comparative glycomic analysis of hawk (Rupornis magnirostris), caiman (Caiman latirostris) and sea turtle (Caretta caretta) tear films #MolOmics #MassSpec pubs.rsc.org/en/content/a...

📣 Present your research at EMBL’s The Epitranscriptome (28–30 Oct)!
🧬 RSC Chem. Biol. & Molecular Omics are sponsoring poster prizes.

🗓️ Abstract deadline: 5 August – submit now!
👉 www.embl.org/about/i...
#Epitranscriptome #RSCChemBio #MolOmics #ScienceSky

Temperature- and time-dependent degradation of mouse tissue proteins: insights into RNA-binding protein stability via mass spectrometry In proteomics research, samples are frequently stored at −20 °C and −80 °C for extended periods, and assessing protein stability under these conditions is essential. We evaluated protein stability in ...

Temperature- and time-dependent degradation of mouse tissue proteins: insights into RNA-binding protein stability via mass spectrometry #MolOmics pubs.rsc.org/en/content/a...

Advancing colorectal cancer research through lipidomics Colorectal cancer (CRC) is currently a global health burden, with staggering worldwide prevalence. CRC is ranked as the third most common and second deadliest cancer worldwide. With rising life expect...

Advancing colorectal cancer research through lipidomics #MolOmics #MassSpec pubs.rsc.org/en/content/a...

Lipid profiling: proving the geographical origin of strawberries (Fragaria × ananassa) using a non-targeted LC-IM-MS approach The strawberry, a globally traded fruit, is a prime example of how geographical origin has become an important marketing factor. Significant price differences between countries of origin make mislabel...

Lipid profiling: proving the geographical origin of strawberries (Fragaria × ananassa) using a non-targeted LC-IM-MS approach #MolOmics pubs.rsc.org/en/content/a...

Exposing Halogenated Airborne Pollutants by Non-Targeted Screening of Passive Samplers Using Ion Mobility-Mass Spectrometry Air pollution poses significant risks to human health and the environment, necessitating comprehensive monitoring and analysis to identify and mitigate the presence of harmful pollutants. This study focuses on Hamilton and Sarnia, Ontario, Canada, known for their industrial activities and associated air pollution challenges. Employing gas chromatography coupled with ion mobility spectrometry and high-resolution mass spectrometry (GC-IMS-MS) on samples collected by polyurethane foam passive samplers, we aimed to uncover the presence of halogenated airborne organic pollutants, including those not typically monitored in standard air quality assessments. Our research successfully identified 19 groups of halogenated pollutants in the air samples. These include a range of chlorinated and brominated anisoles, as well as a previously undocumented polyfluoroalkyl substance (PFAS) that was confirmed with a synthesized standard. Polychlorinated biphenyls (PCBs), chlorinated organophosphate esters (OPEs) and various agricultural contaminants were also tentatively identified based on mass spectral interpretation. The study revealed significant differences in the pollutant profiles between the two cities, reflecting their distinct industrial influences. The application of non-target screening techniques also highlighted the complex nature of air pollution and the necessity for broader monitoring strategies to protect public health and the environment.

Exposing Halogenated Airborne Pollutants by Non-Targeted Screening of Passive Samplers Using Ion Mobility-Mass Spectrometry #MolOmics pubs.acs.org/doi/10.1021/...

Integrating N-glycan and CODEX imaging reveal cell-specific protein glycosylation in healthy human lung Identifying cell-specific glycan structures in human lungs is critical for understanding the chemistry and mechanisms that guide cell–cell and cell–matrix interactions and determining nuanced function...

Integrating N-glycan and CODEX imaging reveal cell-specific protein glycosylation in healthy human lung #MolOmics #MassSpec pubs.rsc.org/en/content/a...

Analysis of FAIMS for the study of affinity-purified protein complexes using the orbitrap ascend tribrid mass spectrometer In this study, we analyzed the combination of affinity purification mass spectrometry (AP-MS) with high-field asymmetric waveform ion mobility spectrometry (FAIMS), integrated between nanoLC-MS and an...

Analysis of FAIMS for the study of affinity-purified protein complexes using the orbitrap ascend tribrid mass spectrometer #MolOmics pubs.rsc.org/en/content/a...

Lipidomics reveals cell specific changes during pluripotent differentiation to neural and mesodermal lineages Due to their self-renewal and differentiation capabilities, pluripotent stem cells hold immense potential for advancing our understanding of human disease and developing cell-based or pharmacological ...

Lipidomics reveals cell specific changes during pluripotent differentiation to neural and mesodermal lineages #MolOmics #MassSpec pubs.rsc.org/en/content/a...

Unmasking the lipid landscape: carbamazepine induces alterations in Leydig cell lipidome Leydig cells rely on lipids and fatty acids (FA) for essential functions like maintaining structural integrity, energy metabolism, and steroid hormone synthesis, including testosterone production. Car...

Unmasking the lipid landscape: carbamazepine induces alterations in Leydig cell lipidome #MolOmics #MassSpec pubs.rsc.org/en/content/a...

Selective labeling of tyrosine residues in proteins: insights from PTAD labeling and tandem mass spectrometry analysis Designing reagents for protein labeling is crucial for investigating cellular events and developing new therapeutics. Historically, much effort has been focused on labeling lysine and arginine residue...

Selective labeling of tyrosine residues in proteins: insights from PTAD labeling and tandem mass spectrometry analysis #MolOmics pubs.rsc.org/en/content/a...

Phosphoproteomics guides low dose drug combination of cisplatin and silmitasertib against concurrent chemoradiation resistant cervical cancer Cisplatin-based concurrent chemoradiotherapy (CCRT) is the standard treatment for cervical patients with locally advanced disease. Despite the improved survival rates and prognosis observed in patient...

Phosphoproteomics guides low dose drug combination of cisplatin and silmitasertib against concurrent chemoradiation resistant cervical cancer #MolOmics #MassSpec pubs.rsc.org/en/content/a...