🧠 Non-linear blood-brain barrier #BBB transport & dosing influence #receptor #occupancy ratios of #morphine and #MorphineMetabolites (M3G + M6G) in the #pain matrix.
💡This might also explain some inter-individual differences!
🔗 bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
#ChronicPain #opioids
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