FGF8-expressing embryonic body Organizer fusion induced rostral-caudal arealization of elongated hPSC-derived cortical assembloids (15-mm long😎)

Modeling FGFR3-related temporal lobe dysgenesis

#NatMeth 2024
www.nature.com/articles/s41...

3d-OT
Spatial Multi-omics Alignment

Spatiotemporal reconstruction of🐭embryonic heart (+blood vessels) brain lung liver muscle (E11.5~16.5)

Geometry-aware, soft correspondence optimal transport-based
Chamfer Distance as a performance metric

#NatMeth 2026
www.nature.com/articles/s41...

SpatialGlue
Spatial multi-omics integration
#GraphNeuralNetwork
Intra-modality + Inter-modality dual-attention

spatial epigenome (ATACseq, CUT&Tag)–transcriptome (Stereo-CITE-seq)–proteome (SPOTS)

vs Seurat totalVI MultiVI MOFA+ MEFISTO scMM StabMap

#NatMeth 2024
www.nature.com/articles/s41...