Study Identifies Glial-to-Mesenchymal Shift Driving NF1 Tumor Malignancy New research suggests that glial-to-mesenchymal reprogramming and Sox9 upregulation appear central to NF1-related malignant transformation.

Half of malignant peripheral nerve sheath tumors in humans arise from #Neurofibroma progression, and current therapeutic options remain ineffective.

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#NF1 #RareDisease #NeurofibromatosisType1

#systematicreview #review #evidence #ebm #study of pacinian neuromas and #neurofibroma of the hands and fingers #handsurgery

journals.sagepub.com/doi/full/10.1177/1753193...