Incidence and severity of SARS-CoV-2 infection and vaccine BNT162 side effects in children and adolescents with Noonan Syndrome: a national multicentric study

🧪🩺🧬🦠 No statistically significant differences were found in the severity or duration of COVID-19 between NS patients and controls. No statistically significant differences in side effects from the BNT162 vaccine were observed between groups. #Medsky #IDsky #noonan pubmed.ncbi.nlm.nih.gov/41602885/

So excited to see this. Investment in small molecule drugs targeting #Noonansyndrome #RASopathy #RAS #MAPK signaling.
By far the most common gene mutated in #Noonan syndrome is PTPN11 encoding SHP2 protein tyrosine phosphatase. Congrats to Think Biosci.
🧪💊🧬🩺

ClearSky ClearSky - Bringing information closer to you

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#PEGGY #NOONAN
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Pulmonary hypertension in patients with Noonan syndrome - PubMed Precapillary and postcapillary PH may complicate the course of NS, potentially in association with congenital heart defects and multisystem manifestations. Further studies are needed to better delineate the phenotype of PH in patients with NS.

🧪🫁 Haven't heard too much about pulmonary hypertension in #Noonan syndrome before. Here is a report from one center.
pubmed.ncbi.nlm.nih.gov/41381222/

Multidisciplinary Treatment of Patients With Noonan Syndrome This consensus statement develops recommendations for diagnosis, treatment, and follow-up from childhood through adulthood for patients with Noonan Syndrome.

Multidisciplinary Treatment of Patients With Noonan Syndrome
Consensus on the diagnosis of NS, patient transition from pediatric to adult care, follow-up, and treatment of short stature with recombinant human growth hormone (rhGH).
jamanetwork.com/journals/jam...
#medsky #pedsky #noonan
🧪💪🦴

Ep. 23- First in Flight, Lost in History: The Amelia Earhart Story She was a pioneer, a record-breaker, and a global icon—and then she vanished. For decades, the disappearance of Amelia Earhart has baffled historians and fueled endless theories. In this episode of The Paranoid Perspective, we explore what really might have happened on her final flight. Was it a simple crash, a secret spy mission gone wrong, or something far stranger? Surveillance Feed: Facebook Page: https://www.facebook.com/profile.php?id=61571915435705 Instagram: https://www.instagram.com/the_paranoid_perspective/ Tiktok: https://www.tiktok.com/@theparanoidperspe Bluesky: https://bsky.app/profile/paraperspective.bsky.social YouTube: https://www.youtube.com/@TheParanoidPerspective Patreon: https://patreon.com/TheParanoidPerspective?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLink 

📣 New Podcast! "Ep. 23- First in Flight, Lost in History: The Amelia Earhart Story" on @Spreaker #amelia #aviation #conspiracy #coverup #crash #disappearance #earhart #evidence #expedition #government #island #lockheed #mystery #noonan #ocean #pacific #pilot #plane #search #secrets

Photograph of Amelia Earhart and Fred Noonan .

2 July 1937: Amelia #Earhart & her navigator Fred #Noonan disappeared while flying over the Pacific Ocean. #History

ClinGen #RASopathy VCEP updates ACMG/AMP variant guidelines, enhancing classification for dominant and recessive RASopathies with broader applications to rare disease genomics bit.ly/3H0AF7s #GIMO #VariantInterpretation #MAPK #Noonan #ACMG #AMP #GeneticDiagnosis #ClinGen

Heads up 🗣️
9️⃣ more days of EARLYBIRD rates to register for #RASopathies SYMPOSIUM
Don't miss the opportunity to interact with experts and advocates who will discuss physiological systems and treatment advances related to genetic conditions: #CFC #Noonan #Costello #NF1, #NSML, #Mazzanti syndromes

Fight Club Knockout Stories: Canes, Paddles, 'War Pimps,' and Little Dictators For Breitbart Fight Club Members only, every week we reveal our top five articles based on reader engagement. These are the stories that our readers were talking about for the past week.

www.breitbart.com/politics/2025/03/09/figh...

#Politics #Donald #Trump #Hakeem #Jeffries #Mark #Hamill #peggy #noonan #Stacey #Abrams

Event Attributes

✅️ 🇮🇪 Michael #Noonan se ha convertido en el JUGADOR MÁS JOVEN de la historia en marcar en una competición europea.

➡️ Tiene 16 años y 197 días y superó a Romelu #Lukaku que en su momento logró anotar a los 16 años y 218 días.

Pédiatrie: un médicament contre le cancer pour prévenir de graves problèmes cardiaques Une nouvelle étude observationnelle internationale suscite l’espoir pour les enfants atteints du syndrome de Noonan, une maladie rare causant un épaississement des parois du cœur.

#RECHERCHE | 🔎💡 Découverte d'un traitement pour le syndrome de #Noonan

🧠 Une étude menée par le Dr Gregor Andelfinger suggère que le médicament trametinib pourrait réduire les graves complications cardiaques chez les enfants atteints de la maladie.

🔗 En savoir plus :
liens.umontreal.ca/4apXDzg

Preventing serious heart problems in children A new international observational study offers hope for children with Noonan syndrome, a rare genetic disorder that can thicken the wall of the heart.

#PEDIATRICS One in 2,500 children carries the genetic mutation that causes #Noonan syndrome, and now researchers at @cra-chusj.bsky.social and 26 other institutions worldwide think a #cancer drug can help them. @lmumuenchen.bsky.social nouvelles.umontreal.ca/en/article/2...

Do children with a Noonan syndrome-like RASopathy and avoidant/restrictive food intake disorder benefit from behavioral therapy? - PubMed • Ultimately, these feeding/eating problems may develop into an avoidant/restrictive food intake disorder. • Behavioral therapy (SLIK program) can effectively manage complex feeding/eating problems su...

#pedsky
"More than 50% of infants with Noonan syndrome-like #RASopathy have serious feeding/eating problems. Most of them temporarily need tube feeding." CBT benefits equally well those with ARFID whether they have #Noonan syndrome or not.
pubmed.ncbi.nlm.nih.gov/39710790/

Short stature is common in #RASopathies
In fact, #Noonan syndrome parents often ask for the NS specific growth chart. #CFCsyndrome community wants a chart that 'fits' their natural history. Does this tool incorporate or account for short stature syndromes?

Interestingly, undescended testicles are a common sign in #Noonan syndrome #RASopathies
#pedsky

PTPN11 variants assoc w/ #Noonan syndrome or NS with multiple lentigenes, Case report and lit review. Looks like a signal with Chiari 1 Malformation and Syringomyelia
doi: 10.1002/jdn.10396
#pedsky #neurosky #Noonan #raredisease
Q: Possibly related to tethered cord?
Q: What symptoms r associated?

Novel therapeutic strategies in #Noonan Syndrome and #RASopathies.
from a recent review by Thomas Edouard
doi.org/10.1007/s004...

Can we get #MEK inhibitors over the finish line?

What makes SENS? a social-emotional training for adolescents with #Noonan syndrome beautifully presented by Renée Roelofs and Mandy Mostert-Kerckhoffs from Centrum Voor Neuropsychiatrie

Now, at the @INSneuro webinar organised by the #NeuropscyhologicalInterventions SIG

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#US: Former Reagan speech writer Peggy #Noonan says ‘Mitt, this isn’t working.’” http://on.wsj.com/QlSSu2 via @WSJ #Romney

Anyone else think that Rory McIlroy looks a LOT like this guy? static.reelmovienews.com/images/gallery/danny-noo... #noonan