HappyDerbyDay! #ORSxDerby #KyDerby
Equine acute synovitis model? In @JOrthoPres.bsky.social this model show Liraglutide's anti-inflammatory effect by reducing CCL2 concentrations in whole blood, PBMCs, chondrocytes, and synoviocytes
buff.ly/0OAY8EH
@orssociety.bsky.social #ORSSMC
Animal and human remodeled cortical bone (fractional area of secondary bone) and bone formation rate (bone formation rate per unit of bone volume) with wedge area representing relative amounts and rates
'One health' seeks to overcome health challenges that afflict numerous species. Takashi Taguchi & Mandi Lopez present information on variation in bone healing between different animals: onlinelibrary.wiley.com/doi/10.1002/... #ORSSMC #ORSxDerby @jorthopres.bluesky.social
Recent findings in @JOrthopRes.bsky.social show loss of effective lubricating viscosity is the primary mechanical marker of synovial inflammation in equine OA, linked to inflammation biochemical markers like white blood cell count & PGE2.
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#ORSxDerby #ORSSMC
@ORSsociety.bsky.social
Did you know that Hartley guinea pigs spontaneously develop osteoarthritis (OA), alike humans? Check out Dr. Afzali's paper in @jorthopres.bsky.social utilizing this model system to validate the intravenous delivery of cellular therapies.
Link: buff.ly/evclxZd
#ORSSMC #ORSxDerby
Tomorrow is the Kentucky Derby! In parallel, the #ORSSMC will be posting articles from @jorthopres.bsky.social showcasing how @orssociety.bsky.social members contribute to the success and longevity of animal and human athletes alike. #ORSxDerby #KyDerby #OneHealth π πββοΈ
Link: buff.ly/raqOTGd
(A) The wrist torque measuring equipment consists of a handle (1), a rotation center to measure wrist torque (2), and a table to place the forearms (3). (B) Subjects adjusted the moving handle to ensure the rotation center of the wrist and the rotation center of equipment together. (C) Subjects fixed their forearms on the table.
Lateral epicondylitis, or 'tennis elbow', impacts women more often than men. Kazuhiro Ikeda & coauthors looked at potential causes for this discrepancy, finding sex differences in wrist torque and endurance: onlinelibrary.wiley.com/doi/10.1002/... #ORSxDerby #ORSSMC @jorthopres.bsky.social
This study used caliberated CT to show that bone density changes across the innominate bone due to age and sex tend to vary between individuals, although consistent effects were seen at specific regions. buff.ly/j2Uhe4J
@orssociety.bsky.social #ORSSMC #ORSxDerby #KyDerby #BMD #fracture
Patients w/ Ehlers-Danlos Syndrome (cEDS) present w/ extensible skin & joint instability, with more females affected.
In a mouse model of cEDS, Vet-Scientist Dr. Jaclyn Carlson discovered altered healing in this population.
Link: buff.ly/crnkIwN
#ORSSMC #ORSxDerby
In @JOrthopRes.bsky.social, the Christiansen Lab (UC Davis) reports sex differences in mice post-femur fracture:
𦴠Males show greater systemic bone loss & TNF-α elevation
πͺ Females trend toward greater muscle loss in the injured limb
buff.ly/LfFQjGn
#ORSxDerby #ORSSMC
@ORSsociety.bsky.social
Summary of key examples of answers to 5W1H for preclinical tendon and ligament model selection. 5W1H, why, who, what, where, when, and how.
Like us, horses can injure their tendons and ligaments & often don't recover full tendon or ligament strength. Diane Little, et al. explore preclinical tendon & ligament animal models for developing better treatment: onlinelibrary.wiley.com/doi/10.1002/... #ORSxDerby #ORSSMC @jorthopres.bsky.social
I am honored to highlight Vet-Scientist and past @orssociety.bsky.social president, Dr. Kurt Hankenson!
The Hankenson Lab @umich.edu is interested in elucidating mechanisms of bone formation to improve clinical care.
Spotlight: buff.ly/I8OoHC0
#ORSSMC #ORSxDerby
Meet Dr. Brenna Pugliese, Veterinarian and PhD candidate in the Schnabel Lab at @ncstate.bsky.social . Dr. Pugliese investigates intra-articular therapies for equine patients, with applications toward human health.
Spotlight: buff.ly/1dDyb4O
#ORSSMC #ORSxDerby
Vet-scientists in the @orssociety.bsky.social improve orthopaedic health for animals & humans.
Meet Dr. Kelly Santangelo: buff.ly/K1go4OO
The Santangelo Lab aims to enhance healthspan by aiding functional, independent, & pain-free mobility.
#ORSSMC #ORSxDerby
Great interview with Prof. Mandi Lopez, Professor of Veterinary Surgery in LSU School of Veterinary Medicine ! She shares her career, interests, and life advice for the orthopaedic research community! Check it out here: buff.ly/I8VdeCt
@orssociety.bsky.social #ORSSMC #ORSxDerby #KyDerby
Meet Dr. Dianne Little, DVM, PhD, a vet surgeon & orthopaedic scientist leveraging multi-omics to advance rotator cuff tendon tissue engineering. Her translational work advocates for more inclusive approaches in regenerative medicine. π©βπ¬
buff.ly/3mrzXoF
#ORSxDerby #ORSSMC
@ORSsociety.bsky.social
In honor of the Kentucky Derby this week, the #ORSSMC is excited to highlight some of the stellar Veterinary Scientists in the @orssociety.bsky.social & their research in the areas of #sexdifferences, #animalhealth, and #onehealth. Stay tuned on May 1, 2, & 3 for more! #ORSxDerby #KyDerby
