276 new entries in #PDBrelease (pdbe.org/latest)! Here's the crystal structure of a monooxygenase from 𝑅ℎ𝑜𝑑𝑜𝑐𝑜𝑐𝑐𝑢𝑠 sp. that plays an important role in bacterial degradation of p-nitrophenol (pdbe.org/9j9j). This work is crucial for the development of microbial remediation technology.
276 new entries in #PDBrelease (pdbe.org/latest)! Here's the crystal structure of a monooxygenase from 𝑅ℎ𝑜𝑑𝑜𝑐𝑜𝑐𝑐𝑢𝑠 sp. that plays an important role in bacterial degradation of p-nitrophenol (pdbe.org/9j9j). This work is crucial for the development of microbial remediation technology.
306 new entries in #PDBrelease (pdbe.org/latest)! Including potential COVID-19 treatment 💊 insight. Promising mice 🐁 model results. Papain-like protease:inhibitor complex pdbe.org/9cyd, after screening of 400,000 compounds @wehi-research.bsky.social!
In @naturecomms.bsky.social
357 new entries in #PDBrelease (PDBe.org/latest)!
Citronellal, #EssentialOil from plants found in skin care treatments, now also in our database! Citronellal (pdbe.org/chem/A1EBV) binds to TRPV3 ion channel found in skin cells (pdbe.org/9je5).
@naturecomms.bsky.social
209 new entries in #PDBrelease (http://PDBe.org/latest Here's the cryo-EM derived structure of a photosystem II complex with a Lys317Ala mutation that reveal new insights into proton egress through the conserved chlorine (Cl1) hydrogen-bonding channel (http://PDBe.org/9eh5
286 new entries in #PDBrelease (http://PDBe.org/latest Here's the cryo-EM derived structure of the DNA polymerase of African swine fever virus which is a highly fatal disease in swines (http://PDBe.org/8ywm This study will be crucial for the development of antiviral drugs. @NAR_Open
364 new entries in #PDBrelease (http://PDBe.org/latest Here's the cryo-EM derived structure of the human GABAA receptor of β2–α1–β3–α1–γ2 assembly (http://PDBe.org/9cxa GABAA receptors mediate inhibitory signalling in the brain and are targets of important drugs.
@Nature
117 new entries in #PDBrelease (http://PDBe.org/latest Here's the cryo-EM derived structure of the complex between Cas12a, guide RNA and target DNA, resulting in DNA bending that causes base flipping and finally enables Cas12a to recognise target sites within the genome (http://PDBe.org/9cjh
506 new entries in #PDBrelease (PDBe.org/latest)! Including mug-shaped 🍺 chaperone from 𝘏𝘦𝘭𝘪𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳 𝘱𝘺𝘭𝘰𝘳𝘪 (PDBe.org/9gtx) named outer-membrane lipoprotein carrier. #AntimicrobialResistance -- 𝘌. 𝘤𝘰𝘭𝘪, 𝘏. 𝘱𝘺𝘭𝘰𝘳𝘪 vs. polymyxin B.
452 new entries in #PDBrelease (http://pdbe.org/latest Here's the crystal structure of α-carboxysome shell hexamer that unveils the basic principles of protein interactions involved in the shell architecture (http://pdbe.org/8yxu
297 new entries in #PDBrelease (buff.ly/2KQsivl)! Including a designed protein (purple) bound to an extracellular cysteine-rich domain from the tumor necrosis factor receptor superfamily (buff.ly/49r0WWH), TNFR2 (green). AI-generated protein engineering example.
374 new entries in #PDBrelease (pdbe.org/latest)! Here’s the crystal structure of the human arginase 2, an enzyme involved in the urea cycle, in complex with an inhibitor containing a boronic acid warhead (pdbe.org/8rfa). Arginase is a crucial target in immuno-oncology.
224 new entries in #PDBrelease (pdbe.org/latest)! Including a viral protein (yellow) sensed by bacteria by being bound to an antiviral protein (blue) (pdbe.org/9erv). The unbound phage protein (yellow) has a 6-strand β-barrel core (pdbe.org/9axb).
236 new entries in #PDBrelease (pdbe.org/latest)! Including Tau fragment (from microtubule-associated protein) showing a new type of association with microtubule proteins (pdbe.org/9f07) at 2.2A resolution. Tau is found aggregated in Alzheimer's disease.
283 new entries in #PDBrelease (pdbe.org/latest)! GerQ is a spore coat protein involved in 𝐵𝑎𝑐𝑖𝑙𝑙𝑢𝑠 spore germination, that assembles into a structure containing rings of nine subunits, which then stacks to form filaments (pdbe.org/8zra).
242 new entries in #PDBrelease (pdbe.org/latest)!
Here is a new non-standard amino acid, 5-dimethylallyl-tryptophan (CC ID WWB) found in a lasso peptide (pdbe.org/8ukg) from an 𝘼𝙘𝙩𝙞𝙣𝙤𝙢𝙮𝙘𝙚𝙩𝙚𝙨 bacteria ➡️ determined by solution NMR ➡️ published in BiochemistryACS
217 new entries in #PDBrelease (pdbe.org/latest)! Here’s the cryo-EM derived structure of a variant capsid protein from Tulane virus (pdbe.org/9cvf). This provides insights into genetic modifications in viruses enabling them to adapt to different environments.
366 new entries in #PDBrelease (pdbe.org/latest)! Here’s the cryo-EM derived structure of the E. coli GroEL/GroES in complex with the novel inhibitor PBZ1587 (pdbe.org/9c0b). Such small molecules show promise as potential antibiotics.
@ACSPublications
243 new entries in #PDBrelease (PDBe.org/latest)! Such as cartilage acidic protein-1 (pdbe.org/9etn), a secreted single chain glycoprotein found in animal tissues; role in osteoarthritis. Potassium (purple) stablized structure also: calcium & sodium @JmolBiol
304 new entries in #PDBrelease (pdbe.org/latest)! Here’s the cryo-EM derived structure of the flotillin complex, that is implicated in various cellular processes, such as IgE receptor-mediated signaling, and cholesterol uptake and trafficking (pdbe.org/9bq2).
379 entries in this week’s #PDBrelease (PDBe.org/latest)! Including a protein (DdmDE; pdbe.org/8u3k) from bacteria’s defence system. Protein (blue & purples) targets for destruction DNA from foreign plamsids (pinks). 2.5Å Cryo-EM map (www.ebi.ac.uk/emdb/EMD-41865).
349 new entries in #PDBrelease (pdbe.org/latest)! Here is the cryo-EM derived structure of human serum albumin bound to the chemotherapeutic drug, teniposide (pdbe.org/8vac). This study provides crucial information for future drug discovery and development.
320 new entries in #PDBrelease (pdbe.org/latest)! Here’s the crystal structure of a novel fluorophore bound to a RNA aptamer (pdbe.org/8hzd). Enhanced recognition sensitivity of fluorophores have important implications for future biomedical use.
pre-tRNA in orange being held by several proteins with chains coloured various shades of blue. Helices shown as tubes
294 new entries in #PDBrelease (PDBe.org/latest)!
⬇️ tRNA production in mitochondria ⬇️
pre-tRNA, being modified by a RNase Z (pdbe.org/8cbl), while also in complex with proteins TRMT10C & dehydrogenase, SDR5C1. EM map: www.ebi.ac.uk/emdb/EMD-16544
Published in @natcomms
359 new entries in #PDBrelease (pdbe.org/latest)! Here’s the crystal structure of 𝐷. 𝑎𝑒𝑟𝑖𝑢𝑠 C-glucosyl deglycosidase, a part of the enzyme cluster responsible for deglycosylation of aromatic polyketides, important metabolites for plants (pdbe.org/8qvd).
244 new entries in #PDBrelease (PDBe.org/latest), including a 1.12 Å resolution structure of an exotoxin (pdbe.org/8ovs) from pathogen, 𝒀𝒆𝒓𝒔𝒊𝒏𝒊𝒂 𝒆𝒏𝒕𝒆𝒓𝒐𝒄𝒐𝒍𝒊𝒕𝒊𝒄𝒂. This bacterial toxin glycosylates tyrosines on certain GTPases. @biolchem
354 new entries in #PDBrelease (pdbe.org/latest)! The crystal structure of FADD/capspase-8/cFLIP complex is crucial for understanding cellular pathways involved in development, innate immunity & disease (pdbe.org/8yd8).
376 new entries in #PDBrelease (pdbe.org/latest)! Here’s the crystal structure of the soluble glucose dehydrogenase from 𝐴. 𝑐𝑎𝑙𝑐𝑜𝑎𝑐𝑒𝑡𝑖𝑐𝑢𝑠, used in glucose biosensors to detect the presence of glucose (pdbe.org/8rg1).
288 new entries in #PDBrelease (pdbe.org/latest)! Here's the crystal structure of the glycyl aminopeptidase M61xc that exhibits broad specificity & cleaves several amino acids at the N-terminus. This is crucial for recycling of the amino acids (pdbe.org/8j9c).
354 new entries in #PDBrelease (pdbe.org/latest)! Here's the EM-derived structure of SUMO-loaded encapsulin from 𝐾. 𝑝𝑛𝑒𝑢𝑚𝑜𝑛𝑖𝑎𝑒 (pdbe.org/8u51). Encapsulins, self-assembling proteins that can encapsulate cargo proteins, have many biomedical applications.
