Do we know what #PRDM9 does?
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#PRDM9
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Re-read this #PRDM9 paper: striking evidence from salmonids that #PRDM9-driven #recombination hotspots are conserved across vertebrates, with rapid #hotspot #turnover driven by target erosion over hundreds of millions of years 🧬
Highly recommendation and a must read 👉
@academic-chatter.bsky.social
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Top: pictures of Salmo salar and Oncorhynchus mykiss (credit: US Fish and Wildlife Service, public domain). Bottom: Structure of the identified PRDM9 alleles in S. salar PRDM9 α1.a.2 and O. mykiss PRDM9 α1.a.1. Colored boxes represent unique ZFs, characterized by the 3 amino acids in contact with DNA (3-letter code).
PRDM9 helps determine the location of recombination hotspots in many mammals. Study of salmonid fish reveals that #PRDM9 function is conserved across vertebrates, and this peculiar evolutionary runaway caused by PRDM9 has been active for 100s of millions of years🧪 @plosbiology.org plos.io/3DIvFCG
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Top: pictures of Salmo salar and Oncorhynchus mykiss (credit: US Fish and Wildlife Service, public domain). Bottom: Structure of the identified PRDM9 alleles in S. salar PRDM9 α1.a.2 and O. mykiss PRDM9 α1.a.1. Colored boxes represent unique ZFs, characterized by the 3 amino acids in contact with DNA (3-letter code).
PRDM9 helps determine the location of recombination hotspots in many mammals. Study of salmonid fish reveals that #PRDM9 function is conserved across vertebrates, and this peculiar evolutionary runaway caused by PRDM9 has been active for 100s of millions of years🧪 @plosbiology.org plos.io/3DIvFCG
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Top: pictures of Salmo salar and Oncorhynchus mykiss (credit: US Fish and Wildlife Service, public domain). Bottom: Structure of the identified PRDM9 alleles in S. salar PRDM9 α1.a.2 and O. mykiss PRDM9 α1.a.1. Colored boxes represent unique ZFs, characterized by the 3 amino acids in contact with DNA (3-letter code).
PRDM9 helps determine the location of recombination hotspots in many mammals. Study of salmonid fish reveals that #PRDM9 function is conserved across vertebrates, and this peculiar evolutionary runaway caused by PRDM9 has been active for 100s of millions of years🧪 @plosbiology.org plos.io/3DIvFCG
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