I can't have that happen again. So it really reduced the messaging efficacy of this #platform, but there's a lot of opportunity here programmatically. The #AT #protocol is extraordinarily flexible. There are #applications coming, some subscription, that will let fundraising operate pretty well here.

Imaging-Confirmed #Epidemiology of Age-Related Macular Degeneration in Rural Central India: A #Hospital-Based Cross-Sectional #Study #Protocol Date Submitted: Mar 18, 2026. Open Peer Review Period: Mar 25, 2026 - May 20, 2026.

Reminder>> Imaging-Confirmed #Epidemiology of Age-Related Macular Degeneration in Rural Central India: A #Hospital-Based Cross-Sectional #Study #Protocol (preprint) #openscience #PeerReviewMe #PlanP

Artificial Intelligence (AI) in #Psychiatry for Improving Continuity of #Patient Care; Systematic Review #Protocol Date Submitted: Mar 23, 2026. Open Peer Review Period: Mar 25, 2026 - May 20, 2026.

Reminder>> Artificial Intelligence (AI) in #Psychiatry for Improving Continuity of #Patient Care; Systematic Review #Protocol (preprint) #openscience #PeerReviewMe #PlanP

The Submissive May Only Ask to Give Pleasure Pleasure is a precious gift—one to bestow upon others and to treasure deeply. Submissive may not ask for pleasure, however the Submissive may ask to give pleasure to the Dominant, and those the Dominant chooses. This imparts onto the Submissive to not expect, or desire pleasure for themselves, and to focus their efforts on providing pleasure to others.

Unleash your kinky side with daily BDSM fun. #BDSM #Kink #NSFW #Tasks #Scene #Game #Parts #Rule #Protocol #Punishments #Anal #Penetration #Behavior #Manners #Switch #Sexuality #Domestic #Discipline #Self #Penetration #Masturbation #Lust #Arousal #TRAD #Wife #Traditional #Relationships

Spinal Manipulative Therapy on a Healthy Population: #Protocol for a Randomized Blinding Feasibility Trial Background: Few manual chiropractic high velocity, low amplitude (HVLA) type shams have been validated in #Research. The proposed project is a #RCT #ClinicalTrial (RCT) designed to assess a novel, full-spine, manual sham chiropractic maneuver and its blinding success. Objective: This #Study aims to evaluate the blinding integrity of participants receiving a genuine or sham chiropractic maneuver. We will also be evaluating the effects of genuine chiropractic treatments relative to sham chiropractic treatments by measuring several neurophysiological mechanisms. Methods: Participants (N=60) will be recruited from in and around Marietta, Georgia, United States. They will undergo a chiropractic physical exam and health history review with a licensed chiropractor and be randomized to either a sham or genuine chiropractic group (1:1 ratio). Participants, outcome assessors, and data analysts will be blinded to group allocation. The genuine group will receive diversified HVLA chiropractic spinal manipulative therapy (SMT), while the sham group will receive a novel chiropractic HVLA-emulating therapy. Each participant will attend 2 sessions spaced 1 week apart. Assessments will consist of blinding surveys postsessions (both visits) and presession (second visit). Additionally, we will measure gait parameters. The primary outcome of interest is blinding measured via the Bang Blinding Index (Bang BI). Secondary aims include measuring blinding via the James Blinding Index (James BI) and exploring the potential differential effects of genuine versus sham SMT on gait parameters. Results: This #Study is being supported and internally funded by the Dr. Sid E. Williams Center for Chiropractic #Research at Life University in Marietta, Georgia, United States. Our #Study was prospectively registered on clinicaltrials.gov (NCT06931600) on March 28, 2025, and the first participant was enrolled on May 5, 2025. As of December 10, 2025, 18 participants have completed the trial. Projections for completing data collection, data analysis, and manuscript submission are Summer 2026, Fall 2026, and Winter 2027, respectively. Conclusions: The significance of the current RCT will be in its ability to inform whether our novel, full-spine, manual sham SMT #Protocol successfully blinds participants, suggesting feasibility for future clinical trials, as well as assessing for secondary outcome measures between groups. Trial Registration: ClinicalTrials.gov NCT06931600; https://clinicaltrials.gov/#Study/NCT06931600 and Universal Trial Number (UTN) U1111-1321-6250; https://trialsearch.who.int/Trial2.aspx?TrialID=NCT06931600 International Registered Report Identifier (IRRID): DERR1-10.2196/85956

JMIR Res Protocols: Spinal Manipulative Therapy on a Healthy Population: #Protocol for a Randomized Blinding Feasibility Trial

Impact of Antenatal Corticosteroids on Brain Function and Underlying Mechanisms in Preclinical Studies: #Protocol for a Systematic Review Background: Antenatal corticosteroid (ACS) treatment matures the fetal lung and reduces risks of neonatal morbidity and mortality in babies born preterm. However, ACS treatment also impacts the brain and stress regulatory systems, with increasing clinical evidence for adverse long-term impacts. Preclinical studies are important to investigate the mechanisms for these impacts. Objective: This systematic review aims to synthesize the best available evidence describing how in utero exposure to ACS affects brain function, the underlying mechanisms, and the hypothalamic-pituitary-adrenal axis in nonhuman mammalian species. Methods: This review will include peer-reviewed, primary studies that report measures of brain function (eg, learning, behavior) and the underlying mechanisms (eg, brain size, neuron number, myelination, hypothalamic-pituitary-adrenal axis function) in nonhuman mammals exposed in utero to ACS in the second half of pregnancy, in comparison to unexposed individuals. Initial search terms include (corticosteroid* OR glucocorticoid*) AND (antenatal OR fetal* OR pregnan*) AND (brain OR neurodevelopment*). We searched PubMed, Embase, MEDLINE (Ovid), Web of Science, Scopus, and ProQuest for English language publications without date restrictions. Two independent reviewers will perform abstract screening, data extraction, and quality assessment. Antenatal corticosteroid treatment information, #Study design, methods, and outcomes will be reported for each #Study. Results: A narrative synthesis will be presented following standard guidelines. A dose-response meta-analysis will be performed where at least three studies report the same outcome following in utero exposure to the same steroid. As of February 21, 2026, title and abstract screening were completed for 42,024 of 56,493 records, with 40,795 records excluded. Searches will be updated in June-July 2026 to include sources published to the end of 2025. Publication is planned for 2027. Conclusions: This review will inform future #Research including intervention studies to reduce the adverse effects of antenatal corticosteroids on the brain. Trial Registration: PROSPERO CRD420251116681; https://www.crd.york.ac.uk/PROSPERO/view/CRD420251116681 International Registered Report Identifier (IRRID): PRR1-10.2196/84522

JMIR Res Protocols: Impact of Antenatal Corticosteroids on Brain Function and Underlying Mechanisms in Preclinical Studies: #Protocol for a Systematic Review

Development of a Collaborative Education Program for Home Care Nursing Educators’ on-the-Job Training in End-of-Life Home Care: #Protocol for a #RCT #ClinicalTrial Background: Despite the growing demand for end-of-life home care, nursing educators responsible for on-the-job training face substantial barriers, such as time and geographical constraints, which limit their access to professional development. Collaborative online training programs offer a potential solution to these challenges. Objective: This #Study aims to develop and evaluate a collaborative online training program designed to improve the educational ability of home care nursing educators in delivering effective on-the-job training for home-based end-of-life care. Methods: This parallel group, waitlist-controlled trial recruited home care nursing managers or educators from agencies with at least one home death client in the past year. We will provide this program on the internet. The intervention will comprise three online sessions, each lasting 60 minutes and held monthly, involving one lecture and two interactive case studies related to on-the-job training in end-of-life home care. This will be followed by 8 weeks of weekly educational messages via LINE, a mobile messaging #App widely used in Japan. The control group will serve as a waitlist and will receive the same intervention after the control period. The primary outcomes are participants’ attitudes, measured using the End-of-Life Nursing Education Questionnaire. Using a centralized computer-generated randomization system, 125 home care nursing managers and educators will be recruited and randomly assigned to either the intervention or control group at a ratio of 1:1. Stratification will be based on their agency’s annual home death count between November 29, 2023, and November 29, 2024. To minimize performance bias, the intervention content has been standardized before the intervention to ensure fidelity. Results: This #Study was approved by the Ethics Committee of the Graduate School of Medicine, The University of Tokyo (2024359NI-(2)) on November 15, 2024. Participant recruitment began on November 29, 2024, and closed on December 25, 2024, with 120 participants enrolled. As of February 15, 2026, the following number of surveys were completed at each time point: 106 at T0 (the intervention group:the control group; 52:54); 103 at T1 (51:52); 102 at T2 (50:52); 40 at T3 and 43 at T4 in the intervention group; and 47 at T5, 44 at T6, and 41 at T7 in the control group. Quantitative data collection was completed by January 2026, and qualitative interviews will be completed by March 2026. Primary quantitative results and integrated results are expected to be submitted for publication in 2026-2027 and 2027-2028, respectively. Conclusions: This #Protocol can address geographical and time constraints by providing flexible, online educational resources for home care nursing educators. The anticipated outcomes include enhanced on-the-job training ability among nursing educators for home-based end-of-life care. This #Study’s findings could support broader implementation of scalable training strategies in home care settings. Trial Registration: The University Hospital Medical Information Network UMIN000056165; https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000063254 International Registered Report Identifier (IRRID): DERR1-10.2196/84330

JMIR Res Protocols: Development of a Collaborative Education Program for Home Care Nursing Educators’ on-the-Job Training in End-of-Life Home Care: #Protocol for a #RCT #ClinicalTrial

Identification of training needs and development of a work-integrated training program for aged care onsite #Pharmacists: a co-design #Protocol. Date Submitted: Mar 22, 2026. Open Peer Review Period: Mar 23, 2026 - May 18, 2026.

Reminder>> Identification of training needs and development of a work-integrated training program for aged care onsite #Pharmacists: a co-design #Protocol. (preprint) #openscience #PeerReviewMe #PlanP

Active choice clinical decision support to improve provider review of prescription drug monitoring program: A pragmatic randomized hybrid type II trial #Protocol Date Submitted: Mar 19, 2026. Open Peer Review Period: Mar 23, 2026 - May 18, 2026.

Reminder>> Active choice clinical decision support to improve provider review of prescription drug monitoring program: A pragmatic randomized hybrid type II trial #Protocol (preprint) #openscience #PeerReviewMe #PlanP

Expert Consensus on Smoking Cessation and Harm Reduction in Type 2 #Diabetes Mellitus: An International Modified Delphi #Study #Protocol Date Submitted: Mar 20, 2026. Open Peer Review Period: Mar 23, 2026 - May 18, 2026.

Reminder>> Expert Consensus on Smoking Cessation and Harm Reduction in Type 2 #Diabetes Mellitus: An International Modified Delphi #Study #Protocol (preprint) #openscience #PeerReviewMe #PlanP

Kenyan Neonatal Mortality Risk Predictor: #Protocol for a User-Centered Design Evaluation Background: Neonatal mortality remains a major public health challenge in low- and middle-income countries (LMICs), particularly in sub-Saharan Africa, where health systems often lack effective triage mechanisms to identify and prioritize high-risk neonates. Existing clinical tools frequently fail to support timely decision-making during the critical early postnatal period. A previous machine learning (ML)–based neonatal risk prediction model developed using multicountry LMIC datasets demonstrated high predictive accuracy for neonatal mortality in the Indian context, achieving an area under the curve above 0.80. The model incorporates 11 neonatal parameters assessed from delivery through day 2 of life, with birth weight identified as the strongest predictor. Objective: This #Study aims to evaluate the contextual feasibility, applicability, and usability of the neonatal risk predictor variables embedded in the ML model in Kenyan health care facilities to inform potential adoption aligned with national health priorities and global targets, including Sustainable Development Goal 3.2. Methods: A mixed methods feasibility #Study will be conducted through the real-world preimplementation of a neonatal risk assessment tool in 3 Kenyan health facilities that provide neonatal services. Qualitative and quantitative approaches will be combined to strengthen methodological rigor and enhance the credibility of the findings. The #Study will be implemented in 3 sequential phases. Phase 1 will involve key informant interviews to capture contextual insights on existing workflows, stakeholder perceptions, and implementation considerations. Phase 2 will comprise a 4-month intervention period during which a paper-based neonatal risk tool will be integrated into routine clinical workflows to assess feasibility, applicability, and usability. Phase 3 will involve postintervention surveys conducted longitudinally at 2 time points to evaluate outcomes, user experience, and implementation barriers. Results: The neonatal risk predictors are expected to demonstrate strong contextual feasibility, allowing for integration into existing triage systems with minimal workflow disruption. Their applicability is expected to enable early identification of high-risk neonates within the first 48 hours of life, thereby enabling timely clinical decision-making. Usability assessments are expected to indicate positive user experience, acceptability, and perceived usefulness among health care workers. Six participants (frontline neonatal health workers) had been recruited by the time of initial submission of the manuscript (August 2025). Data analysis is ongoing and is expected to be concluded in March 2026. Publication of #Study findings is expected by June 2026. Conclusions: The #Study is expected to generate actionable evidence to support the translation of ML-based neonatal risk prediction into routine clinical practice in LMIC settings, thereby reducing neonatal mortality and advancing progress toward Sustainable Development Goal target 3.2. International Registered Report Identifier (IRRID): DERR1-10.2196/81996

JMIR Res Protocols: Kenyan Neonatal Mortality Risk Predictor: #Protocol for a User-Centered Design Evaluation

Exploring Applications of Artificial Intelligence in the Crisis Line Sector: #Protocol for a Scoping Review Date Submitted: Mar 19, 2026. Open Peer Review Period: Mar 23, 2026 - May 18, 2026.

Reminder>> Exploring Applications of Artificial Intelligence in the Crisis Line Sector: #Protocol for a Scoping Review (preprint) #openscience #PeerReviewMe #PlanP

Follow-Up of Low-Acuity Patients After Redirection From a Swiss Emergency Department Using an Electronic Triage Application: #Protocol for a Single-Center Prospective Cohort #Study Background: Emergency department (ED) overcrowding threatens health care systems worldwide. This poses risks to patient safety, lowers quality of care, and reduces patient satisfaction. Patient input, defined as the caseload of patients presenting to the ED, is one of the factors contributing to overcrowding. Redirecting patients with nonurgent complaints to external health care services could help alleviate ED workload. Objective: The primary objective of this #Study is to investigate the safety and efficiency of redirection of low-acuity patients using an electronic clinical decision support system. As a secondary and exploratory aim, we will assess the impact of this intervention on subsequent health care use, patient satisfaction, and health literacy over a 6-month follow-up period. Methods: A single-center observational #Study with 2 consecutive cohorts of low-acuity patients presenting to the ED will be conducted. The first cohort will be triaged and offered redirection according to current practice. In the second cohort, after triage, low-acuity patients will be evaluated by an electronic clinical support system to determine eligibility for redirection. If eligible for redirection, an appointment at a nearby clinic will be arranged through the system. The primary end point is any unexpected returns to health care services within 48 hours of triage. Secondary end points are patient satisfaction as well as the number of unexpected consultations and the evolution of health literacy during a 6-month follow-up period. Results: This #Study is funded by an internal grant from Hôpital Fribourgeois. Recruitment began on June 20, 2025, with a total of 35 patients enrolled as of August 2025. Data analysis will begin after the recruitment and 6-month follow-up of 300 to 420 patients are completed, which is expected to occur in November 2026. We hope to publish results in December 2026. Conclusions: We expect the redirection process of low-acuity patients to other health care facilities using an electronic clinical support system to be safe and efficient. If results are positive, application of this reproducible strategy could reduce the number of patients treated in EDs and provide alternative health care pathways for low-acuity patients. Trial Registration: ClinicalTrials.gov NCT06971419; https://clinicaltrials.gov/#Study/NCT06971419 International Registered Report Identifier (IRRID): DERR1-10.2196/82195

JMIR Res Protocols: Follow-Up of Low-Acuity Patients After Redirection From a Swiss Emergency Department Using an Electronic Triage Application: #Protocol for a Single-Center Prospective Cohort #Study

Measuring Accuracy (Classification Probabilities, Positive, and Negative Predictive Values) of Executive Function Electroencephalogram Metrics in Attention-Deficit/Hyperactivity Disorder Diagnosis: #Protocol for and Perspectives From the SINCRONIA #Study Background: Attention deficit/hyperactivity disorder (ADHD) is the most prevalent neurodevelopmental disorder worldwide, affecting approximately 5%‐7% of school-aged children and 2%‐5% of adults worldwide. However, there is still no reliable diagnostic tool for it. The lack of specific biomarkers further complicates the accurate diagnosis of ADHD. Objective: The SINCRONIA #Study seeks to develop and optimize an electroencephalogram (EEG)-based ADHD diagnostic classification algorithm by identifying biomarkers that provide optimal diagnostic performance. Methods: This #Protocol introduces a single-center, case-control #Study involving at least 165 participants, aged between 7 and 12 years, that is being conducted at the Puerta de Hierro University Hospital in Madrid, Spain. Participants will be allocated to 3 groups, including ADHD predominantly inattentive, ADHD predominantly combined or hyperactive/impulsive, and a control group, according to the best estimated diagnosis based on clinical interviews and a neuropsychological assessment that includes the Conners Continuous Performance Test. In addition, an EEG recording will be conducted separately, and functional connectivity metrics will be used to characterize brain networks associated with inhibitory control. The index test is expected to match or improve the clinical diagnosis of ADHD in children aged between 7 and 12 years and provide a set of eventual biomarkers that maximize diagnostic performance and provide pathophysiological clues. Results: The SINCRONIA #Study began screening and recruitment in March 2023. Recruitment ended on December 11, 2024. A total of 165 eligible participants were enrolled. Conclusions: The SINCRONIA project is a high-quality, large-scale, unicenter #Study devoted to improving the objective diagnosis of ADHD by using EEG biomarkers. The EEG-based ADHD diagnosis is expected to have greater sensitivity and specificity than the Conners Continuous Performance Test. Trial Registration: ISRCTN Registry ISRCTN12110752; https://doi.org/10.1186/ISRCTN12110752 International Registered Report Identifier (IRRID): DERR1-10.2196/79150

JMIR Res Protocols: Measuring Accuracy (Classification Probabilities, Positive, and Negative Predictive Values) of Executive Function Electroencephalogram Metrics in Attention-Deficit/Hyperactivity Disorder Diagnosis: #Protocol for and Perspectives From the SINCRONIA #Study

Methodological #Research Practices for the Adaptation of Measuring Instruments in Health Care: #Protocol for a Scoping Review Background: The identification of the methodological path followed by #Researchers in psychometric studies can contribute to maintaining the transparency and rigor necessary for the #Study. Objective: This #Study aims to map the methodological practices of adaptation of health measurement instruments. Methods: The #Protocol is based on the method proposed by the Joanna Briggs Institute using the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). The following databases were consulted: MEDLINE, CINAHL, Web of Science, LILACS, the Cochrane Library, and Embase. The search for data in gray literature sources was carried out in the following databases: WorldCat and the Brazilian Portal of Scientific Publications and Open Access Data (O Portal Brasileiro de Publicações e Dados Científicos em Acesso Aberto [OASISBR]). The search strategy was based on the participants, concept, and context framework: participants (#Researchers in methodological practices), concept (studies of adaptation of measuring instruments), and context (health area). The #Research will consider studies on methodological practices adopted to conduct adaptation studies of health measurement instruments. The selection of studies, data extraction, and synthesis will be carried out by 2 independent reviewers. Results: Data collection was carried out in the months of June and October 2025. The results will be presented in a narrative format and with tables or diagrams. The results are being prepared for publication and should be published by March 2026. Conclusions: This #Study will identify the current status and challenges faced by #Researchers in carrying out adaptation studies of health measurement instruments. The findings will contribute to the development of future #Research that promotes better psychometric evidence and advances science in nursing. International Registered Report Identifier (IRRID): DERR1-10.2196/86949

JMIR Res Protocols: Methodological #Research Practices for the Adaptation of Measuring Instruments in Health Care: #Protocol for a Scoping Review

Tunnel Anastomosis vs Double-Tract Jejunal Interposition Reconstruction After Proximal Gastrectomy: #Protocol for a Multicenter Prospective #RCT #ClinicalTrial Background: Tunnel anastomosis is a novel anastomotic technique for digestive tract reconstruction following proximal gastrectomy. A previous retrospective #Study by our team demonstrated its favorable antireflux effect; therefore, we hypothesize that tunnel anastomosis is noninferior to double-tract jejunal interposition reconstruction in preventing postoperative reflux esophagitis, and we will conduct this prospective #Study to further validate this assumption. Objective: In this #Study, we will prospectively compare tunnel anastomosis with the currently more prevalent double-tract jejunal interposition reconstruction technique to further validate its safety and efficacy. Methods: This is a multicenter prospective randomized controlled #Study that will enroll 240 patients who will undergo proximal gastrectomy. The #Study will be divided into 2 groups: the tunnel anastomosis group and the double-tract jejunal interposition reconstruction group, with 120 patients in each group. Patients will undergo clinical assessments and complete questionnaires preoperatively, as well as at the 3rd, 6th, and 12th months postoperatively. The primary end point is the incidence of reflux esophagitis within 1 year. The secondary end points include perioperative safety, postoperative quality of life, and postoperative nutritional status. Results: Recruitment of patients commenced in March 2022 and is scheduled to conclude in February 2027. The follow-up for all enrolled patients will be completed by February 2028. Conclusions: To our knowledge, this is the first prospective #Study on this technique, aiming to provide novel insights into the methods of digestive reconstruction following proximal gastrectomy. Trial Registration: Chinese Clinical Trial Registry ChiCTR2200057397; https://www.chictr.org.cn/showprojEN.html?proj=154418 International Registered Report Identifier (IRRID): DERR1-10.2196/82712

JMIR Res Protocols: Tunnel Anastomosis vs Double-Tract Jejunal Interposition Reconstruction After Proximal Gastrectomy: #Protocol for a Multicenter Prospective #RCT #ClinicalTrial

Impact Assessment of the Allergy Fact Checker, a Clinical Decision Support Tool for Noninvasive Beta-Lactam Antibiotic Allergy Label Delabeling: #Protocol for a Multicenter Crossover Cluster-Controlled #Study Background: Beta-lactam allergy labels (BLALs), especially penicillin allergy labels, are frequently recorded in hospitalized patients and are associated with increased use of broad-spectrum and second-line antibiotics. Most BLALs are incorrect, but current allergy workups require invasive testing and specialized resources. We recently developed a strictly noninvasive, electronic patient record–embedded clinical decision support tool, the Allergy Fact Checker (AFC), which proactively identifies potentially incorrect BLALs by detecting uneventful re-exposures to the culprit or other beta-lactams since introduction of the BLAL. Objective: This #Study aims to evaluate the clinical, antimicrobial, and economic impact of the AFC in hospitalized adults with BLALs compared to the standard of care (no AFC). Methods: We are conducting a multicenter, open-label, crossover cluster-controlled #Study in 9 hospitals in Flanders, Belgium. All hospitalized adults with a BLAL are eligible, excluding patients in palliative care, discharged within 24 hours, or previously enrolled. Each hospital will alternate between intervention (use of the AFC) and control (standard practice) phases, separated by washout periods. The primary endpoint is cumulative guideline-concordant prescribing of first-line and/or narrow-spectrum beta-lactams following local antibiotic treatment guidelines, across predefined care windows up to day 100, expressed as a weighted per-patient proportion. Secondary endpoints include delabeling or refinement rate, beta-lactam tolerance, antibiotic switching, hospital length of stay, in-hospital and 3-month mortality, intensive care unit admission, readmission, multidrug-resistant organism colonization or infection, and costs. Based on prior data, we calculated that a total of 3285 participants are required to achieve 80% power to detect superiority of the intervention (4.6% vs 9.9% appropriate prescribing). Recruitment started in March 2025 and is ongoing. Results: The primary outcome will be analyzed using hierarchical mixed-effect models accounting for hospital-level clustering and period effects. Data collection will continue until 200 days after the last patient is discharged. This trial is expected to conclude in 2026. Ethical approval was obtained from the institutional review board in November 2024. Recruitment started in March 2025 and is ongoing. As of manuscript submission, more than 3000 participants have been enrolled across the participating hospitals. According to the prespecified #Protocol, an interim assessment of nuisance parameters will be performed in the following month to evaluate the initial design assumptions. Data collection is expected to continue until the end of 2026. The main #Study results are anticipated to be reported in 2027. Conclusions: This is the first multicenter European #Study evaluating a strictly noninvasive BLAL delabeling approach. If successful, this AFC tool could improve antimicrobial stewardship, reduce costs, and provide a scalable model for centralized allergy label management. Trial Registration: ClinicalTrials.gov NCT06771440; https://clinicaltrials.gov/#Study/NCT06771440 International Registered Report Identifier (IRRID): DERR1-10.2196/86056

JMIR Res Protocols: Impact Assessment of the Allergy Fact Checker, a Clinical Decision Support Tool for Noninvasive Beta-Lactam Antibiotic Allergy Label Delabeling: #Protocol for a Multicenter Crossover Cluster-Controlled #Study

Application of the ADAPT Framework to Contextualize a Participatory Learning and Action Community Intervention for the Prevention and Control of Type 2 #Diabetes Mellitus in Urban and Rural Settings in Afghanistan and Pakistan: #Protocol for Intervention Adaptation Background: Type 2 #Diabetes mellitus (T2DM) is a critical global health issue, especially in low- and middle-income countries like Afghanistan and Pakistan, where many cases remain undiagnosed and specialized care is costly. Community Health Participatory #Research, which actively involves community members in addressing health issues, is increasingly recognized as an effective approach to deliver sustainable and culturally relevant health solutions. Participatory Learning and Action (PLA), a method of Community Health Participatory #Research, was implemented in the D-Magic (#Diabetes Mellitus: Action Through Community Groups or #mHealth Information for Better Control) trial in Bangladesh that empowered communities to identify challenges and develop locally relevant strategies to prevent and control T2DM. Objective: This #Study aims to adapt the PLA-based D-Magic intervention for the prevention and control of T2DM in rural and urban communities of Afghanistan and Pakistan. Methods: This trial, titled “Engagement of Community Through Participatory Learning and Action for Control and Prevention of Type 2 #Diabetes and Its Risk Factors” (EMPOWER-D), will systematically adapt the D-Magic intervention using the ADAPT guidance framework. The #Study will be conducted across 3 sites: rural Afghanistan (Kabul), rural Pakistan (Peshawar and Swabi), and urban Pakistan (Karachi). Stakeholders and community members will be involved to ensure cultural relevance and authenticity. The process includes identifying barriers and facilitators to the implementation of community-based interventions through a qualitative #Study and a scoping review, co-designing intervention materials, and piloting for feasibility and effectiveness. Results: EMPOWER-D was funded and launched in November 2022 by the United Kingdom’s National Institute for Health and Care #Research (NIHR203248). Following a year-long development phase, the adaptation #Protocol was finalized, and a mock run of the interviews was conducted. Recruitment and qualitative data collection, including in-depth interviews and focus group discussions, began in July 2024 and have been completed in Peshawar, Swabi, and Karachi. As of January 2025, data collection has commenced in Afghanistan. Results are anticipated to be published in mid-2026 following the completion of data analysis. Conclusions: The EMPOWER-D adaptation will align the PLA-based intervention with the local sociocultural context, ensuring health equity and participation. Building on the D-Magic trial’s success, this adaptation will ensure the intervention’s effectiveness and cost-effectiveness in preventing and managing T2DM, not only in Afghanistan and Pakistan but also in other low- and middle-income countries. Trial Registration: ClinicalTrials.gov NCT06561126: https://clinicaltrials.gov/#Study/NCT06561126; NCT06570057: https://clinicaltrials.gov/#Study/NCT06570057; NCT07350694: https://clinicaltrials.gov/#Study/NCT07350694 International Registered Report Identifier (IRRID): DERR1-10.2196/71602

JMIR Res Protocols: Application of the ADAPT Framework to Contextualize a Participatory Learning and Action Community Intervention for the Prevention and Control of Type 2 #Diabetes Mellitus in Urban and Rural Settings in Afghanistan and Pakistan: #Protocol for Intervention Adaptation

Original post on belloflostsouls.net

Atomic Mass Games: Friendly PSA – Studio Roadmap Stream Tonight Atomic Mass Games will be presenting their Studio Roadmap at AdeptiCon 2026 tonight! Here’s when and where you can watch! If you...

#Army #Painter #Asmodee #MARVEL #Crisis #Protocol #Star […]

[Original post on belloflostsouls.net]

Original post on belloflostsouls.net

Atomic Mass Games: Friendly PSA – Studio Roadmap Stream Tonight Atomic Mass Games will be presenting their Studio Roadmap at AdeptiCon 2026 tonight! Here’s when and where you can watch! If you...

#Army #Painter #Asmodee #MARVEL #Crisis #Protocol #Star […]

[Original post on belloflostsouls.net]

OpenAI's Codex gets plugins All three major AI coding agents now bundle MCP servers, skills, and app integrations into installable packages.

OpenAI’s Codex gets plugins OpenAI this week announced that it is adding plugins to Codex. These plugins for third-party services like Box, Figma, Linear, The post OpenAI’s Codex gets plugins a...

#AI #AI #Agents #Developer #tools #Model #Context #Protocol

Origin | Interest | Match

OpenAI’s Codex gets plugins OpenAI this week announced that it is adding plugins to Codex. These plugins for third-party services like Box, Figma, Linear, The post OpenAI’s Codex gets plugins a...

#AI #AI #Agents #Developer #tools #Model #Context #Protocol

Origin | Interest | Match

RE: https://social.wake.st/@liaizon/116295265570757213

A good thread on #vibecoding and #theFediverse. Excerpt:

"i think this just tests the #protocol and what people want to do with it to the limits, we're seeing vibe coded AT Protocol #PDSes too!

Definitely highlights rough or under defined […]

Impact of Enhanced Family Education on BMI Changes in Children and Adolescents With Overweight or Obesity: #Study #Protocol for a City-Wide Cluster #RCT #ClinicalTrial Background: The prevalence of obesity among children and adolescents has become a critical global public health issue, particularly in China, with significant increases observed over the past few decades. Despite regular surveillance for overweight and obesity in the past decades, there have been no annual reports provided to parents, resulting in a significant underrecognition of this issue. Early intervention and enhanced family-based educational intervention are necessary to address this growing problem. Objective: This #Protocol aims to evaluate the effectiveness of an enhanced family-based educational intervention in reducing overweight and obesity among school-age children and adolescents. Methods: This #Study uses a stratified cluster #RCT #ClinicalTrial design involving 40 schools from 4 cities in Guangdong Province, selected based on economic levels and overweight and obesity prevalence. Schools will be randomly assigned to intervention or control groups. The intervention group receives an enhanced family-based educational intervention on obesity prevention, including health reports and educational materials. The control group continues with regular practices, including routine physical examinations, general health education activities, and school-based physical activity programs. The intervention spans 9 months, followed by a 3-month follow-up. Data on BMI, waist circumference, and waist-to-height ratio are collected at baseline and after 12 months to assess the potential effectiveness of the intervention. Results: This trial was funded in January 2024 and registered in the Chinese Clinical Trial Registry on November 5, 2024. Recruitment was completed in December 2024, with 20 schools enrolled in each of the intervention and control groups. Baseline data collection was completed during the 2024 fall semester, and follow-up data collection continued through December 2025. Data analysis will start after completion of the 12-month assessments. The #Study findings are expected to be published in 2026. Conclusions: This #Study #Protocol addresses the urgent need for effective interventions to combat the increasing prevalence of childhood and adolescent obesity in Guangdong Province. Given the significant underrecognition of the need for consistent reporting to parents, the proposed enhanced family-based educational intervention aims to fill this gap by raising parental awareness and promoting healthier lifestyles among children and adolescents. If successful, this approach could significantly reduce the risk of overweight and obesity in Chinese populations, which account for approximately one-fifth of the world’s population. The findings will provide insights into the efficacy of family-centered interventions and underscore the importance of integrating routine parental reporting into existing surveillance programs. Trial Registration: Chinese Clinical Trial Registry ChiCTR2400091909; https://www.chictr.org.cn/showprojEN.html?proj=239755 International Registered Report Identifier (IRRID): DERR1-10.2196/86508

JMIR Res Protocols: Impact of Enhanced Family Education on BMI Changes in Children and Adolescents With Overweight or Obesity: #Study #Protocol for a City-Wide Cluster #RCT #ClinicalTrial

Protocol for pro-inflammatory microRNA motif discovery using machine learning Here, we present a protocol to identify nucleotide motifs that predict the pro-inflammatory property of microRNAs (miRNAs) using machine learning. We describe steps for cell culture, miRNA transfection, pro-inflammatory classification, and k-mer discovery. We detail procedures for combining in vitro macrophage assays with exhaustive motif searches and least absolute shrinkage and selection operator (LASSO) regression to define nucleotide sequence features that distinguish pro-inflammatory miRNAs...

Protocol for pro-inflammatory microRNA motif discovery using machine learning #protocol #starprotocols #cellpress

Community Health Worker–Integrated Model for Sickle Cell Disease Management: #Protocol for a Feasibility #Study Background: Sickle cell disease (SCD) is a chronic inherited blood disorder that disproportionately affects African Americans. Managing SCD is complex, often requiring coordination of care among multiple health care professionals. These care challenges result in fragmented service delivery and poor health outcomes. Integrating community health workers (CHWs) into patient-centered coordinated care may enhance disease management and patient satisfaction with the care received. Objective: The proposed #Study aims to test the feasibility and acceptability of a CHW-integrated model for SCD management. Methods: This #Protocol is for a multimethod #Study to evaluate the feasibility of an integrated CHW intervention. The intervention includes CHW-led patient education and care coordination. Adults with SCD (aged 18‐45 years) will be recruited from the Augusta University Sickle Cell Center’s satellite clinic in Albany, Georgia. Quantitative outcomes include self-care behaviors and patient satisfaction. Qualitative data from semistructured interviews will be used to assess the acceptability of the intervention. Results: The proposed #Study will provide preliminary data on the impact of a CHW-integrated model on care coordination and self-management among adults with SCD. As of March 2026, we have enrolled 16 participants. Conclusions: Despite national calls for improved care coordination and disease management in this population, few published #Protocols detail community-based, culturally aligned approaches that center on the lived experiences and structural barriers faced by adults with SCD. Our #Study addresses a gap in the literature by highlighting a theory-informed, multimethod #Study #Protocol for evaluating the feasibility, effectiveness, and acceptability of integrating CHWs into a patient-centered coordinated care model for adults with SCD. This #Protocol outlines a scalable, community-embedded strategy that may inform future clinical trials and implementation efforts. International Registered Report Identifier (IRRID): DERR1-10.2196/82663

JMIR Res Protocols: Community Health Worker–Integrated Model for Sickle Cell Disease Management: #Protocol for a Feasibility #Study

Protocol for isolating viable human central nervous system T cells Brain-resident T cells act as sentinels, monitoring and supporting immune surveillance and homeostasis. Here, we present a rapid protocol for isolating viable T cells from post-mortem human brain tissue. We describe the process of extracting cells from multiple CNS compartments—including choroid plexus, leptomeninges, dura mater, cerebrospinal fluid, and parenchyma—as well as matched peripheral blood. We detail steps for achieving this through mechanical and enzymatic tissue dissociation, follow...

Protocol for isolating viable human central nervous system T cells #protocol #starprotocols #cellpress

Development of a Line of Care for the Health of People Who Engage in Chemsex: #Protocol for a Multimethod #Study Background: Chemsex, defined as the intentional use of psychoactive substances to enhance sexual experiences, is associated with increased risk of sexually transmitted infections (STIs), mental health harms, and disruptions in continuity of care, particularly among Men Who Have Sex With Men #msm. In Brazil, health services lack an integrated, stigma-sensitive care pathway (CP) for prevention, clinical management, and harm reduction. Embedding a CP within the Health Care Network (HCN) is essential to organize access, continuity, and quality of care. Objective: This #Study aims to develop an evidence-informed CP for people who engage in chemsex, grounded in the needs of users, managers, and health professionals within the HCN, and supported by educational tools and implementation strategies. Methods: This sequential multimethod #Study is guided by the Knowledge-to-Action framework. Phase 1 (predevelopment) focuses on establishing partnerships and mapping the local context. Phase 2 (Knowledge Creation) includes (1) cross-sectional surveys with adults from the general population (target n≈1600) to estimate chemsex prevalence and associated factors, and with managers (n≈54) and health professionals (n≈135) to assess knowledge, attitudes, practices, barriers, and stigma; (2) a scoping review following established methodological guidelines; and (3) triangulation and concept mapping to integrate quantitative and qualitative findings. Data will be collected via REDCap (#Research Electronic Data Capture), online and in person, during testing events. Quantitative analyses will involve descriptive statistics and regression models. Interviews and focus groups will undergo thematic analysis supported by Nvivo software. Educational products will be developed and evaluated for appearance, content, and usability by experts using a content validity index ≥0.78 as a cutoff. Phase 3 (Action Cycle) includes adapting knowledge to the local context, co-designing and validating the CP with stakeholders, piloting implementation in priority municipalities, and establishing monitoring processes. Process indicators (eg, number of trained professionals, educational activities, rapid tests performed, and #App engagement) and outcome indicators (eg, STI testing and linkage to care, service use across the HCN) will be monitored through official information systems. Results: Ethical approval was obtained in April 2025. Recruitment and data collection began in June 2025 through online and in-person strategies. By December 2025, 3061 individuals had been screened online, and 1723 participants had undergone rapid testing for STIs. Data collection is expected to conclude by June 2026, followed by data cleaning and preliminary analyses between April and June 2026, inferential and qualitative analyses between July and September 2026, and CP development and validation between October and December 2026. Conclusions: This #Protocol will generate a CP tailored to chemsex and validated educational resources to support harm reduction, mental health, and STI prevention within the HCN. Findings are expected to inform inclusive policies, reduce stigma, and strengthen care coordination within Brazil’s Unified Health System.

JMIR Res Protocols: Development of a Line of Care for the Health of People Who Engage in Chemsex: #Protocol for a Multimethod #Study

Protocol to isolate, expand, and activate human type 2 innate lymphoid cells to study immune checkpoint function Type 2 innate lymphoid cells (ILC2s) are a subset of innate lymphoid cells involved in allergic diseases, tissue repair, and tumor immunity. Here, we present a protocol to study the function of immune checkpoint receptors on ILC2s in vitro using plate-bound recombinant ligands. We describe steps for the enrichment, expansion, and purification of human ILC2s from healthy donors’ peripheral blood. For complete details on the use and execution of this protocol, please refer to Ciancaglini et al.1

Protocol to isolate, expand, and activate human type 2 innate lymphoid cells to study immune checkpoint function #protocol #starprotocols #cellpress

Imaging-Confirmed #Epidemiology of Age-Related Macular Degeneration in Rural Central India: A #Hospital-Based Cross-Sectional #Study #Protocol Date Submitted: Mar 18, 2026. Open Peer Review Period: Mar 25, 2026 - May 20, 2026.

Imaging-Confirmed #Epidemiology of Age-Related Macular Degeneration in Rural Central India: A #Hospital-Based Cross-Sectional #Study #Protocol (preprint) #openscience #PeerReviewMe #PlanP