Aging and Viral Evolution Impair Immunity Against Dominant Pan‐Coronavirus‐Reactive T Cell Epitope The immunodominant pan-coronavirus epitope iCope spans amino acids 816–830 within the fusion domain of the SARS-CoV-2 spike glycoprotein. This region exhibits a comparatively low mutation rate, espec...

Age and viral evolution reduce CD4⁺ T cell reactivity to the conserved iCope epitope, while humoral cross reactivity remains mutation sensitive only. 
#ImmuneEscape #TCellImmunity #PanCoronavirus

👤EVBC: Andreas Nitsche
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A Universal Coronavirus Vaccine Pushing Forward (NextGen Covid Vax Update 30) - Absolutely Maybe A big first this month for next generation coronavirus vaccine. The first clinical trials for a US-developed pancoronavirus vaccine have been under…

This is how the pandemic ends. Not before, not until.

Please, make it so. Those of us who still care aren’t any less sick of COVID (sick ‘with’ COVID, but that’s for another thread) #Pancoronavirus #Vaccine

Newly Discovered Antibody Protects Against All COVID-19 Variants Researchers have discovered an antibody able to neutralize all known variants of SARS-CoV-2, the virus that causes COVID-19, as well as distantly related

"Newly discovered antibody SC27 protects against [numerous] Covid19 variants," [via UT Austin] 🧪🦠

Replaced "All" in the title with 'numerous.' A bit of a stretch to count in future variants as well, yeah?

news.utexas.edu/2024/09/03/n...

#covid19 #variants #pancoronavirus #antibody #SC27 #SpFN

nytimes.com

Scientists are working on a shot that could protect against #Covid19, its variants, certain seasonal colds — and the next coronavirus pandemic. #pancoronavirus #vaccine www.nytimes.com/2021/02/09/health/univer...