#PostTest Q2️⃣ #TumorBoardTuesday
🧐A 75yo♀️w/ ER+/HER2- PIK3CA+ mBC starts 2L Tx w/alpelisib + fulvestrant. Baseline A1C = 6.1 & BMI = 33. What steps can limit risk for severe hyperglycemia❓
1) Labs QW x 2, then Qmonth
2) Baseline A1C, then Q3 months
3) Consider metformin premed
4) All of the above
#PostTest Q1️⃣ #TumorBoardTuesday
🤔What 2L Tx would you offer a 45yo♀️w/ ER+/HER2- mBC and an AKT mutation on 🧪liquid biopsy after progression at cycle 47 of ribociclib ➕ AI/OFS❓
1) Capecitabine monotherapy
2) Capivasertib + fulvestrant
3) Elacestrant monotherapy
4) Everolimus + fulvestrant
#PostTest Q1️⃣ #TumorBoardTuesday
👉🏽#CME Eval 🔗 integrityce.com/TBTeval24
👉🏽ALL CME🔗 integrityce.com/TBT2024
#PostTest Q2️⃣ #TumorBoardTuesday
👉🏽 Free CME 🔗 integrityce.com/TBT2024
🧐 Which of the following would you select for a 78-year-old man w/ mPDAC (CLDN18.2, 45%; MSS; gBRCA WT) and disease progression after gemcitabine/abraxane❓
1) FOLFIRINOX
2) Regorafenib trial
3) CLDN18.2 BiTe trial
4) Pembrolizumab
#PostTest Q1️⃣ #TumorBoardTuesday
👉🏽#CME Eval 🔗 integrityce.com/TBTeval24
👉🏽ALL CME🔗 integrityce.com/TBT2024
🤔What percentage of pancreatic adenocarcinoma cases typically express Claudin 18.2?
1) 30%
2) 50%
3) 70%
4) 90%
#PostTest Q2️⃣ #TumorBoardTuesday
👉🏽 Free CME 🔗 integrityce.com/TBT2024
Which is likely to be optimal for HR+ mBC that progresses after 1Y of 1L ribociclib + AI and harbors an ESR1 Y537S mutation?
Abemaciclib + fulvestrant
Imlunestrant + abemaciclib
Elacestrant
Capivasertib + fulvestrant
#PostTest Q1️⃣ #TumorBoardTuesday
👉🏽#CME Eval 🔗 integrityce.com/TBTeval24
👉🏽ALL CME🔗 integrityce.com/TBT2024
Per INAVO120 data in ET-refractory, PIK3CA+ HR+ la/mBC, adding inavolisib to palbociclib + fulvestrant improved mPFS to:
9 months
12 months
15 months
18 months
#PostTest Q2️⃣ #TumorBoardTuesday
👉🏽 Free CME 🔗 integrityce.com/TBT2024
🧐 Which neoadjuvant therapy would you select for stage 3B, PD-L1+ EGFR/ALK WT NSCLC ❓
A. Chemo
B. Immunotherapy
C. Chemo-immunotherapy
D. Alectinib
#PostTest Q1️⃣ #TumorBoardTuesday
👉🏽#CME Eval 🔗 integrityce.com/TBTeval24
👉🏽ALL CME🔗 integrityce.com/TBT2024
🤔Which neoadj/adj sequence is likely best for a Pt with stage3B (T4N2) EGFR+ NSCLC, PD-L1=1%❓
A. Chemo-RT -> osi
B. Osi -> Adj Chemo -> osi
C. Adj Chemo-RT -> osi
D. Durva-Neoadj Chemo -> osi
