#RespiratoryPathology

This is a photo of a hematoxylin and eosin-stained microscope slide with three irregularly shaped sections of tissue. All three include sheets of darkly staining cells. The two sections to the left are covered by a thin layer of epithelium and the subepithelial connective tissue is rarefied, consistent with edema.

This is a higher magnification of the slide previously described. Longitudinal sections of a few muscle fibers are on the left side of the tissue. Sheets of cells with dark, basophilic (purple) nuclei are present on the right side and constitute the bulk of the sample. A small number of these cells extend between myofibers. A bit of hemorrhage is scattered within the mass.

This is a high magnification image of the mass previously described. Most of the cells have abundant eosinophilic cytoplasm and round to oval nuclei with lightly stippled chromatin and 1 to 2 small nucleoli. A contiguous region that is about 1/3 of the right side of the image is composed of cells with similary nuclei, but smaller amounts of more basophilic cytoplasm. Mostly cell borders are indistinct but rare cells are set off by clear space and they are round. Rare cells have cytoplasmic inclusions in the nuclei.

What's your dx? Laryngeal mass in a dog. We don't see too many of these in veterinary medicine. I'm curious if the MD's think it's a slam dunk without IHC.

#PathSky #VetPath #Veterinary #RespiratoryPathology #Pathology

Multiple nodules (slightly polypoid) protruding from nasal mucosa of a dog. The nodules are only slightly darker pink than the more normal mucosa.

Large, perhaps 200-micrometer-diameter, spherical organisns with a trilaminar wall and multiple smaller structures inside. It lies in the submucosa of the nose and is surrounded by macrophages, lymphocytes and plasma cells.

Spherical organisms of variable diameter but typically very large, with a thick capsule and grainy contents. These structures have thick walls, but only the largest has a trilaminar wall. The organisms are in the submucosa of the nose and are surrounded by macrophages, lymphocytes and plasma cells. Some macrophages contain hemosiderin.

Large spherical organisms of variable diameter with a thick capsule and granular contents. Some have a nucleus visible in the center. The largest is partially collapsed and has a trilaminar wall. The walls of smaller (developing) organisms only have one layer.

Here is a bipartisan #pathology case. It's relevent to DVMs and MDs. Lots of red (at least pink) and blue, too.

Rhinoscopy and nasal biopsy from a dog. What’s your diagnosis? It's a classic.

#vetpath #pathsky #Mesomycetozoea #pathology #respiratorypathology #endoscopy #rhinoscopy