Milk-derived osteopontin influences the composition of the intestinal intraepithelial lymphocyte compartment Abstract. Osteopontin is a protein with many physiological roles widely expressed by many cell types, tissues, and bodily fluids, including breastmilk. The

Read the latest #SMIMemberPaper from Danyvid Olivares-Villagómez and colleagues in ImmunoHorizons on breast milk derived osteopontin in the development of IELs. Read more here: academic.oup.com/immunohorizo...

#MucosalImmunology #Immunology

Esophageal motility disorders after COVID-19 infection - Scientific Reports Scientific Reports - Esophageal motility disorders after COVID-19 infection

Read the latest #SMIMemberPaper by Marko Banić and colleagues on the worsening of esophageal motility post #COVID19. This observational study opens new questions on the lingering effects of COVID19 on people with pre-existing conditions.

Read more here: www.nature.com/articles/s41...

Epidermal growth factor receptor controls sex differences in lung type 2 responses to inhaled allergen Female mice have exacerbated, EGFR-dependent lung type 2 immunity when exposed to inhaled house dust mite throughout sexual maturation.

Read the latest two #SMIMemberPaper by Clare Lloyd and colleagues in Science Immunology and Journal of Allergy and Clinical Immunology.

Read here:
www.science.org/doi/10.1126/...
www.jacionline.org/article/S009...

#MucosalImmunology #Immunology

Serum IgG Response to a Conserved Domain of Commensal Flagellins Predicts Future Risk of Crohn’s Disease in First-degree Relatives Elevated antimicrobial antibodies have been reported up to 6 years before diagnosis of Crohn’s disease (CD), but the specific antibody response is unclear. Here, we characterized the antimicrobial ant...

Read the latest #SMIMemberPaper by Croitoru and colleagues in @AGA_CGH. The CCC-GEM Project has found a new predictor for #Crohns in anti-flagellin IgG antibodies in first degree relatives of Crohns patients. Read more here: www.cghjournal.org/article/S154...

#MucosalImmunology

Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice Food-specific immunoglobulin E (IgE) triggers life-threatening anaphylaxis; however, for unclear reasons, some people with food-specific IgE are asymptomatic upon allergen consumption. We studied stra...

Read the latest #SMIMemberPaper by Stephanie Eisenbarth and colleagues in Science Magazine on how leukotrienes in the intestine control Food Allergy responses. Read more: www.science.org/doi/10.1126/...

Read the latest #SMIMemberPaper by Ludvig Sollid and colleagues in JCI on how interferon gamma promotes hyperplasia in intestinal crypts in #Celiac. Read more -> www.jci.org/articles/vie...

Gut mucosal immune responses – Implications for celiac disease and food allergy The intestinal mucosa employs a diverse set of defense mechanisms—from mucosal barrier regulation to immunoregulatory pathways—to maintain homeostasis…

SMI member Valerie Abadie reviews gut mucosal immune responses and their implications for celiac disease and food allergy at Seminars in Immunology: www.sciencedirect.com/science/arti...

#SMIMemberPaper #MucosalImmunology #Immunology

SMI Member Eduardo Villablanca and colleagues review B cells in inflammatory bowel disease at Immunology Letters:
www.sciencedirect.com/science/arti...

#SMIMemberPaper #MucosalImmunology #Immunology

SMI member De’Broski R Herbert and colleagues show TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni in this work from the Journal of Immunology:
academic.oup.com/jimmunol/adv...

#SMIMemberPaper

Six degrees of TGFβ - Nature Immunology TGFβ-mediated signals enable CD8+ T cells to establish tissue-residence. IL-4 and PD-1 are each connected to TGFβ signaling to regulate the formation of CD8+ T cell tissue residence in skin.

SMI Member Martin Prlic discusses recent publications in "Six degrees of TGFβ" www.nature.com/articles/s41...

#SMIMemberPaper

Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge - Nature Communications Here the authors show that lung epithelial, fibroblast, and endothelial cells retain an imprint of influenza A infection, including increased MHCI/II expression and that re-infection is quickly controlled by a localized antiviral response acting before memory T cells are required.

SMI member Megan MacLeod and colleagues explore how influenza virus alters lung structural cells which can contribute to rapid immune protection following re-challenge in Nature Communications.

www.nature.com/articles/s41...

#SMIMemberPaper

SMI Member R Lee Reinhardt reviews type-2 respiratory responses in "An Outside-In View of the Beneficial and Detrimental Impact of Type-2 Inflammation in the Lung" ->

onlinelibrary.wiley.com/doi/10.1111/...

#SMIMemberPaper #MucosalImmunology

Rapid group-2 innate lymphoid cell mobilization from the intestine aids in early lung defense and repair Can et al. show that circulating group 2 innate lymphoid cells (ILC2s) rapidly migrate from the intestine to the lung after helminth infection. These early responders bolster type-2 immunity and barri...

Gut-lung crosstalk: Rapid group-2 innate lymphoid cell mobilization from the intestine aids in early lung defense and repair from SMI member Lee Reinhardt
@cp-cellreports.bsky.social

cell.com/cell-reports...

#SMIMemberPaper #MucosalImmunology #Immunology

Placental inflammation-driven T cell memory formation promotes allergic responses in offspring via endogenous glucocorticoids Maternal exposure to environmental change during pregnancy is a critical determinant of offspring health and disease. Previous epidemiological studies…

Placental inflammation-driven T cell memory formation promotes allergic responses in offspring via endogenous glucocorticoids in this work from SMI member Heung Kyu Lee: www.sciencedirect.com/science/arti...

#SMIMemberPaper #MucosalImmunology #Immunology

A Unique Presentation of Early‐Onset Colon Cancer in the Setting of Helicobacter pylori Positivity, IgA Deficiency, and a Germline 18p Deletion Click on the article title to read more.

A Unique Presentation of Early-Onset Colon Cancer in the Setting of Helicobacter pylori Positivity, IgA Deficiency, and a Germline 18p Deletion from SMI Member Smita Dandekar, onlinelibrary.wiley.com/doi/10.1002/...

#SMIMemberPaper

Machine Learning of Serum Cytokine and Chemokine Profiles Can Classify Inflammatory Bowel Disease Beyond Clinical Diagnosis from SMI member Tadakazu Hisamatsu.
www.sciencedirect.com/science/arti...

#SMIMemberPaper

Frontiers | Effector Tc17 cells resist shift from OXPHOS to aerobic glycolysis IL-17A-expressing lymphocytes, including Tc17 cells, are instrumental in immunity, immunopathology, and autoimmunity. We have previously shown that experimen...

Read the latest #SMIMemberPaper by @NanjappaSom and colleagues in @FrontImmunol on the metabolism of long-lived L-17A-producing CD8+ T (Tc17) cells. Read here: www.frontiersin.org/journals/imm...

A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma - Nature Immunology Here, the authors use single-cell spatial transcriptomics to profile the airway wall landscape in health and during asthma. Discrete proinflammatory ecosystems containing alarmins, chemokines and a un...

Read the latest #SMIMemberPaper by Clare Lloyd lab and colleagues in Nature Immunology on the spatial distribution of immune cells in normal and inflamed lung during asthma.

Read more here: www.nature.com/articles/s41...

IRF4-regulated transcriptional and functional heterogeneity of lung-resident CD11b+ cDC2 subsets during influenza virus infection The Editors have selected this article as a highlight of the issue.

Read the latest #SMIMemberPaper by Susan Kovats and colleagues in The Journal of Immunology on lung-resident conventional dendritic cells during influenza infection.

Read more here: academic.oup.com/jimmunol/art...

Cathelicidin-related antimicrobial peptide (CRAMP) is toxic during neonatal murine influenza virus infection The Editors have selected this article as a highlight of the issue.

Read the latest #SMIMemberPaper by Alison Carey and colleagues in the Journal of Immunology on neonatal influenza A infection and how commensal bacteria can reduce mortality. Read more here: bit.ly/44DiXPk

Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation A high-salt diet increases Bacteroides abundance and intestinal propionate, activating the HIF-1α–TGF-β1 axis and promoting glioma invasion. This study rev

Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation from SMI member Heung Kyu Lee and colleagues, online at the Journal of Experimental Medicine (JEM).

rupress.org/jem/article/...

#Immunology #MucosalImmunology #SMIMemberPaper

📢 New #SMIMemberPaper from the labs of Régis Joulia and Clare Lloyd - Location matters: defining the mucosal landscape of the bronchial wall in health and asthma.

🔗 www.socmucimm.org/resources/ne...

#Asthma #Immunology #SingleCell regisjoulia.bsky.social‬ lloydlab.bsky.social

Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function - Nature Communications Prior studies implicate an allele near laccase domain containing 1 (LACC1) for risk of Crohn’s disease and decreased LACC1 expression in T cells. Using human genome analyzes and mouse genetic models, ...

SMI Member Mitch Kronenberg and colleagues connect Crohn’s Disease-associated genetic variants to modulation of T cell gene expression, metabolism and T cell function: nature.com/articles/s41...

#SMIMemberPaper

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...

SMI member Jie Sun and colleagues explore how tissue sequelae during SARS-Cov2 can be limited by macrophages, allowing tissue regeneration: www.science.org/doi/10.1126/...

#SMIMemberPaper

On tending sprouts: empowering emerging immunologists in Latin America Supporting emerging immunologists in Latin America and the Caribbean (LAC) is crucial amidst fragile funding and policy shifts in the region. Their gr…

New #SMIMemberPaper! Marion Brunck & colleagues explore how SMI’s Mentorship Program empowers emerging immunologists in Latin America & the Caribbean. With fragile funding & policy shifts, supporting these scientists is more crucial than ever.

🔗 Read more: www.sciencedirect.com/science/arti...

Read the latest #SMIMemberPaper by Gerard Kaiko and colleagues in Respirology APSR on the role of CFTR in non-eosinophilic asthma. The authors identify a loss of CFTR-ionocytes due to inflammation in human samples opening the avenue for new drug targets. onlinelibrary.wiley.com/doi/10.1111/...

Identification of antigen-presenting cell–T cell interactions driving immune responses to food The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal ant...

Read the latest #SMIMemberPaper by Daniel Mucida and colleagues in Science Magazine where they used the elegant proximity labeling method (LIPSTIC) to track APC and T cell interactions in the gut to dietary antigens. Read more here -> www.science.org/doi/10.1126/...

Freeze-dried fecal microorganisms as an effective biomaterial for the treatment of calves suffering from diarrhea - Scientific Reports Scientific Reports - Freeze-dried fecal microorganisms as an effective biomaterial for the treatment of calves suffering from diarrhea

Read the latest #SMIMemberPaper by Tomonori Nochi and colleagues in Scientific Reports on how #FMT can be optimized to counter intestinal diseases in cattle, a major issue for the livestock industry. www.nature.com/articles/s41...

Read the latest #SMIMemberPaper by Kenneth Croitoru and colleagues in AGA Gastroenterology on the findings of the Crohn’s and Colitis Canada (CCC) Genetic, Environmental, Microbial (GEM) Project Research Consortium.

www.gastrojournal.org/article/S001...