If you missed Kernel's latest poster at #SOBP2025 last month, you have a chance to catch it at #APAAM25 this month!
🧠 Developing a Treatment Decision-Making Aid for Major Depressive Disorder Using Functional Brain Measures
📅 Sat 5/17 1:30-3pm
📍 Exhibit Hall, LACC
@apapsychiatric.bsky.social
Grateful for the chance to attend #SOBP2025 in Toronto—learned a lot from lectures and symposia, especially on how AI might shape mental health care. Had inspiring exchanges during my poster session with colleagues from around the world. @uni-muenster.de @trr393.bsky.social @traplabms.bsky.social
Jam-packed past few weeks celebrating @katycelina.bsky.social’s paper acceptance, a new paper submission, hosting Dr. Toru Takumi, and attending #SOBP2025 in Toronto with @neuroash.bsky.social @siyaoneuro.bsky.social and #SONA2025 at @westernu.bsky.social with (almost) the whole lab crew! 🥳🍾🤩
My first #SOBP was awesome! There were so many great sessions where I learned about the neurobiological underpinnings of #depression and new treatments the field is adopting. Thanks to all who came by my poster #SOBP2025
One sentence that stayed with me from the #SOBP2025 fireside chat:
'Science cannot help society if it does not reflect society.'
A little late, but still feeling energized after #SOBP2025! I‘m super grateful for the chance to reconnect with familiar faces and the ability to meet new colleagues.
Congratulations !!@drchristineannd.bsky.social and all the team for this amazing work 💪🏼👏👏👏 @brikchen.bsky.social wonderful presentation of this work #SOBP2025 proud of you 👏😉 #Ketamine #5HT4R #Moodisorders
So proud of Chris Thomas, my research technologist, for presenting his poster at #SOBP2025! His research using deep learning to explore spontaneous fMRI in clinical groups is outstanding. Big things ahead! #Neuroscience #DeepLearning #BrainResearch
So I finally got my Society for Biological Psychiatry travel award 🎉 I remember the feeling I had when I got award email for 2024, a mix of happiness and "ugh, not another US visa app" feeling. Funny enough, I applied and it is still processing 14 months later 😴 luckily the #SOBP2025 was in Toronto
Loved learning more about the awesome work @robynmcquaid.bsky.social and Ayeila Daneshmend are doing on the #epigenetics of #suicide #SOBP2025
Feeling so inspired & energized by all the *awesome * work by trainees at #sobp2025! + very cool sessions on new technology & AI .. thanks your leadership @frangoulab.bsky.social !!🙌🇨🇦🧠 @enigmabrains.bsky.social @dehughes.bsky.social
Great job to Chris 👏
He picked one hell of a data model for his first ever poster presentation. It fit in perfectly with all of the talks I went to this week. Moral of the week… people are special, stop averaging 🥲 #SOBP2025
Had a great time at #SOBP2025 with these amazing people!
Wrapping up a wonderful 3 day celebration of biological psychiatry at #SOBP2025 in Toronto. Strong representation from the Ottawa clinical neuroscience community 🧠👩🏽🔬📊
Well #SOBP2025, it's been good fun! Lots of exciting work being done, and I look forward to further integration of statistical genetics into brain science in future!
Lost my voice almost all the #SOBP! Could not present for my #early-career panel and my poster! #worst #SOBP2025 ever!
#SOBP2025
Several taxa have significant associations with PRS for taxa. Validated across multiple cohorts.
Microbial PRS are associated with remission to sertraline (not surviving multiple comparisons)
#SOBP2025
Host genetics affect microbiome composition. Generate polygenic risk scores for heritable taxa.
18k mostly EUR participants from multiple studies. Correlation of PRS with microbiome 16S data.
#SOBP2025
Integration of experimental models and early human experiments argued for a role of microbiome in mental health.
Microbiome is a confluence of lots of factors, including numerous environments and host genome — think about hologenomes (host+microbes)
#SOBP2025
We contain multitudes, more microbes than cells in body, so microbes have a lot of influence on us.
Microbiome is a function of host genetics and environment, so it's a good candidate for individual differences.
Microbiota-gut-brain axis. Continual crosstalk of host and microbiome
#SOBP2025
Brain is wired early, so day to day changes are probably mostly in the body, and the microbiome is a vital part of that.
Millions (trillions) of bacteria across our bodies, more similarity of regions across people than within person.
#SOBP2025
Three goals : microbiome has value. Host genetics affects microbiome. The confluence of the two influences treatment.
Lack of treatment isn't necessarily the issue as much as failure to match individuals to treatments. Who are the responders? How is the body influencing the brain?
#SOBP2025
Finally (before posters and sleep and probably some kind of zoo and then a plane), Jane Foster will talk about polygenic risk scores for heritable gut microbes predicting antidepressant response.
#SOBP2025
Neural oscillations and individual depression symptoms. Ongoing work in CANBIND and EMBARC. Symptoms from QIDS. Canonical correlation analysis between EEG power and specific symptoms, significant relationship with delta and atypical-like symptoms. Seems to be robust and generalisable
#SOBP2025
Modulation of neural oscillations in escitalopram treatments: pubmed.ncbi.nlm.nih.gov/39396045/
#SOBP2025
Prediction of general antidepressant response - P3 amplitude at pretreatment during go/no-go predicted response to first line treatments
