SOX10, MITF, and microRNAs: Decoding their interplay in regulating melanoma plasticity Recent studies show that the dysregulation of the transcription factor SOX10 is essential for the development and progression of melanoma. MicroRNAs (miRNAs) can regulate the expression of transcript....

We reconstruct a complex #microRNA network that cross-talks with #SOX10 and #MITF to regulate #tumor plasticity. Network analysis shows miRNA-mediated circuits control signaling pathways - driving phenotype switching, stemness & therapy resistance in #melanoma.
doi.org/10.1002/ijc....

#sox10 and neural crest development in #zebrafish embryo—a beautiful movie from Takamiya et al.