Schweinfurthins and their analogues are highly selective cellular probes for oxysterol-binding protein (OSBP) Schweinfurthins (SWs) are natural products isolated from the plant genus Macaranga which display a unique cytotoxicity profile in human cancer cell lines with low nanomolar potency. Their known target...

Happy to share our latest paper in @rscmedchem.rsc.org as part of their 5-year anniversary collection! We carried out comprehensive SAR analysis of natural and synthetic analogues of the #Schweinfurthins, highly potent and selective inhibitors of #OSBP! (1/n) pubs.rsc.org/en/content/a...