A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation - Nature Communications Walport & coworkers report cell-active, potent and selective cyclic peptide modulators for the enzyme peptidylarginine deiminase PADI4/PAD4, including an inhibitor, an activator and an affinity mo...

Unveiling PADI4 regulation, this study offers a cyclic peptide toolkit to explore its role in autoimmunity, cancer & fibrosis, enhancing our understanding within cells. #SciTechInnovation #BiomedResearch #LifeSciences PMID:39528459, Nat Commun 2024, @NatureComms doi.org/10.1038/s414...