⏩#GLP1 #Serotonin, the body’s multitasking maestro #DGBIs💡 🎯A blueprint for developing #orally active small-molecule secretagogues capable of activating the body’s own incretin sensors & gut-brain axis👏 📢The advent of GLP-1–based therapies has reshaped modern metabolic medicine, providing unprecedented efficacy in treating diabetes and obesity. Yet, these advances rely heavily on injectable hormone mimetics #semaglutide #tirzepatide 🎯Transform EC and L cells into tunable therapeutic switches—enabling mechanism-based, physiological treatments for diabetes, obesity, and disorders of gut–brain communication‼️ 🎯Through #neuropod synapses, EECs transmit real-time information about nutrient composition to the brain—forming a crucial component of #interoception, the body’s sense of internal state 🎯A detailed map of human enteroendocrine cell function & receptor signaling—laying the foundation for oral therapies that stimulate endogenous hormone secretion🌟 ⏩Description and functional validation of human enteroendocrine cell sensors @ScienceMagazine👏 👉 https://www.science.org/doi/10.1126/science.adl1460

Dive deep into our latest #GastroDigest @aga-gastro.bsky.social 🆕🔥
🚨Turning #GutSensors into Therapeutic Switches: A #Sensorome Roadmap for Metabolic & Gut–Brain🧠Interaction Disorders‼️ @amergastroassn.bsky.social 🙌
Prof. Kara Margolis🙏😇
👉 www.gastrojournal.org/article/S001...
#DGBI #GLP1 #Serotonin