#ShrewCrew

🧪From the start of the #shrewcrew in 2019, we knew the growth-shrink-regrowth cycle was ⚡️centered, but how to show it? Liver mRNA, 🩸proteins&metabolites show 📈🍂fat metabolism, ❄️gluconeogenesis 👇🏽 bsky.app/profile/labd...

A delight to draw, a derogatory term for women and they can die of fright...so me :) x #ShrewCrew

🤩🤩🤩In a year of this shrew paper doi.org/10.1016/j.cu... and this other one doi.org/10.1098/rsbl... @cecibaldoni.bsky.social thinks this is it? 🥂👊🏽 #shrewcrew

Summary of dynamic changes in shrew metabolism associated with seasonal size change, with proposed regulation of Dehnel’s cycle. Depleted lipid metabolites in the blood and increased RNA expression of genes involved in fatty acid metabolism indicate rapid fat turnover in winter juveniles. FOXO signaling regulates gluconeogenesis, also upregulated in winter juveniles, providing another energy source. Both FOXO signaling and fatty acid metabolism promote changes in oxidative phosphorylation, as was found in both the transcriptomic and proteomic analyses, and have large effects on mitochondrial respiration in the liver.

🧪New #shrewcrew #OA @genomeresearch.bsky.social 📃shows how tiny shrews remain active in ❄️❄️! As it gets 🥶tiny mammals hibernate or migrate, but not shrews. They shrink, thus reducing their overall⚡️demand 👉🏽 genome.cshlp.org/content/earl... 1/4

Rare seasonal brain shrinkage in shrews is driven by water loss, not cell death Common shrews are one of only a handful of mammals known to flexibly shrink and regrow their brains. This rare seasonal cycle, known as Dehnel’s phenomenon, has puzzled scientists for decades. A study...

Scientists discover the secret behind the shrew’s amazing ability to shrink their brains 🧠

The clever trick sheds unwanted weight without compromising too much on cognition.

Find the 5-letter word 👇

Study by @cecibaldoni.bsky.social Dechmann Lab #shrewcrew et al

www.ab.mpg.de/743885/news_...

#shrewcrew

🚨 Out today in eLife! 🚨 @HFSP-funded postdoc Bill Thomas & #shrewcrew reveal how common shrews shrink their brains in winter! 🧠 Seasonal RNA changes in the hypothalamus hint at parallels in mammalian aging. 📖 doi.org/10.7554/eLif... @DinaDechmann @dechmannlab @aspcorthals @RichardGHunter1

(3/3) We also found a subset of genes related to the development and progression of neurological disorders in humans, which may be of therapeutic relevance for treating these diseases #shrewcrew
@DinaDechmann @dechmannlab @aspcorthals @RichardGHunter1