Three-Year-Follow-Up of the NOTION-2 Trial: TAVR Versus SAVR to Treat Younger Low-Risk Patients with Tricuspid or Bicuspid Aortic Stenosis | Circulation Background: Transcatheter aortic valve replacement (TAVR) is increasingly performed in younger, low surgical risk patients. This NOTION-2 study reports mid-term outcomes in low-risk patients aged 60-7...

1/ #AHAJournals #ESC2025 #SimPub alert

🫀The NOTION-2 trial presents 3-year outcomes for 370 low-risk patients, aged 60-75 with a mean STS score of 1.2%, who have severe AS and were randomized to either TAVR or surgery.
🫀27% of these patients had a native bicuspid valve.

🔗 bit.ly/4g9zwYI

#ESC #SimPub on PRADA II Trial: Can sacubitril/valsartan prevent anthracycline ± trastuzumab–related cardiotoxicity in early breast cancer? 138 women randomized, ARNI vs placebo, followed 18 months with CMR, echo GLS, troponins, NT-proBNP.

🧵Thread summarizing key findings:

New in #JACC, our observational IPD analysis of the relationship between blood pressure & outcomes in HFpEF from 4 trials (n~17,000):
🔹I-PRESERVE
🔹TOPCAT-Americas
🔹PARAGON
🔹DELIVER

SBP showed a J-shaped relationship with CV outcomes with lowest risk at SBP 120-130mmHg

#Simpub #AHA24 bit.ly/3Z4tMsi