Structural cartoon models of human S1PR1 in complex with Gi1, scFv16, and each of the four agonists: CYM5442, HY-X-1011, Ponesimod, or SAR247799. S1PR1 is colored marine, Gαi1 pale green, Gβ1 light blue, Gγ2 wheat, scFv16 gray, and agonists yellow.
#Sphingosine -1-phosphate receptors #S1PRs play complex roles in several pathological processes. #CryoEM structures of four agonist-bound S1PR1-Gi1 complexes reveal the structural determinants underlying agonist selectivity among different subtypes @plosbiology.org 🧪 plos.io/4co0A4W
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