Why is it so hard to rewrite a genome? Synthetic biologists have the know-how and ambition to retool whole genomes. But the hidden complexity of biological systems continues to surprise them.

Every genome-rewriting program to date has grappled with substantial and unexpected challenges. “We underestimated how complex biology is”. @eisensteinium.bsky.social dives into the difficulties underlying genome-level synthetic biology. #synthbio 🧪 @nature.com

Challenging the standard view of mind! @drmichaellevin argues evolution leverages math/computation, with body & mind construction being symmetrical. Cognitive patterns may ingress from a non-physical "Platonic space." #embodiedcognition #AI #synthbio

youtu.be/vT48g6uvTHI

#BookSky
#SciFi

I've read a lot of #BioSynth or #SynthBio ideas.

But for me it's always about Sentience.

Sentience comes in 2 forms:
#NaturalLife - All naturally evolved life forms
#CreatedLife - #Clones, #Augmented, #Digital

CRISPR-GPT: An LLM Agent for Automated Design of Gene-Editing Experiments The introduction of genome engineering technology has transformed biomedical research, making it possible to make precise changes to genetic information. However, creating an efficient gene-editing sy...

One step closer to having tools to create new forms of life

www.biorxiv.org/content/10.1...

#AI #LLM #CompBio #SynthBio

Smelling hood, monitor & plaque

Christina Agapakis/ Ginkgo Bioworks, Alexandra Daisy Ginsberg & Sissel Tolaas Resurrecting the Sublime, 2019 Smell diffusion hood, limestone boulder, animation At what point are we the destroyers of species and of worlds? Could we ever again smell flowers driven to extinction by humans? This question is the motivation for an ongoing collaboration between artist Alexandra Daisy Ginsberg, smell artist and researcher Sissel Tolaas, and researchers from Ginkgo Bioworks, led by Creative Director Christina Agapakis. Ginkgo's scientists extracted DNA from specimens stored at Harvard University's Herbaria, then used synthetic biology to predict and resynthesize gene sequences expected to encode for fragrance-producing enzymes. Tolaas then used identical or comparative smell molecules to try to reconstruct the smell of the Orbexilum stipulatum, or Falls-of-the-Ohio scurf pea, a flower last seen in 1881 on Rock Island, near Louisville, Kentucky. Its island habitat was then lost forever with the

Also cool smelling extinct flower!
"Scientists extracted DNA from specimens at Harvard Herbaria & used #synthbio to predict & resynth genes expected to encode fragrance-producing enzymes....to reconstruct smell of Orbexilum stipulatum...a flower last seen in 1881"
(attn: @smellosopher.bsky.social)

Present and future of synthetic cell development - Nature Reviews Molecular Cell Biology Scientists are captivated by the prospect of creating a fully synthetic cell, offering the potential to revolutionize biology, medicine and biotechnology. In this Viewpoint, a panel of experts discuss...

📜 Present and future of synthetic cell development

🧑‍🔬 Katarzyna P. Adamala, Marileen Dogterom, Yuval Elani, Petra Schwille, Masahiro Takinoue & T-Y Dora Tang

📔 Nature Reviews Molecular Cell Biology

🔗 www.nature.com/articles/s41...

#️⃣ #SynthBio #CellBiology #SyntheticBiology