Trajectory of beta cell function and insulin clearance in stage 2 type 1 diabetes: natural history and response to teplizumab - Diabetologia Aims/hypothesis We aimed to analyse TrialNet Anti-CD3 Prevention (TN10) data using oral minimal model (OMM)-derived indices to characterise the natural history of stage 2 type 1 diabetes in placebo-tr...

Changes in insulin secretion & clearance predict progression in stage 2 type 1 diabetes & response to teplizumab. Oral-minimal model identifies disease heterogeneity in stage 2 #T1D link.springer.com/article/10.1... 🔓 #TrialNet #T1Dprevention