Keenova Announces Promising New Findings on TERLIVAZ® at SHM Converge Conference #United_States #Dublin #Terlipressin #Keenova #HRS-AKI
Mallinckrodt to Showcase Innovative Terlipressin Findings at the 2025 AASLD Annual Meeting #United_States #Washington_D.C. #Mallinckrodt #Hepatorenal_Syndrome #Terlipressin
Mallinckrodt to Showcase Terlipressin Research at Kidney Week 2025 #United_States #Houston #Mallinckrodt #CKD #Terlipressin
Data presented earlier this month at #DDW2025 focused on #terlipressin for HRS-AKI. What do the new studies add to the conversation? #acutekidneyinjury #hepatorenalsyndrome #HRSAKI #nephsky #nephrology #hepatology www.docwirenews.com/post/new-dat...
✨ #PosterTour today at #EASLCongress 2025:
All our 3 Horizon2020 #LiverResearch projects in 1 session!
Topic: #Cirrhosis & #PortalHypertension
Chair: Maria Papp
💡 Big moments:
#AMMON-OHE model for post-#TIPS #encephalopathy (Rajiv Jalan)
#Terlipressin response in AKI-HRS w/ CKD (Frank Uschner)
A pleasure to share knowledge re: HRS over @CWRUdeptMED @UHhospitals grand rounds. Thanks to @CLDFoundation for terrific content and some of the updated data re: #terlipressin #livertwitter @CWRU_GI https://youtu.be/FAcCesdNN9g
“To those about to use #terlipressin, we salute you”
#terlivaz #livertwitter onlinelibrary.wiley.com/doi/10.1111/apt.17195
Link to the full @US_FDA label for #terlipressin as well as the black box warning below #LiverTwitter
www.accessdata.fda.gov/drugsatfda_docs/label/20...
Other important considerations when prescribing #terlipressin
⛔️ If experiencing hypoxia or worsening respiratory symptoms
⛔️ If ongoing coronary, peripheral, or mesenteric ischemia
If listed with #MELD>35 risk may outweigh benefit d/t risk of becoming ineligible #LiverTwitter
Highlights of #terlipressin aka #terlivaz label are it’s limitations of use:
. Cr >5 unlikely to benefit
. Volume overloaded or those with 3 or more organ failures (ACLF-3) at high risk for respiratory failure
. Do not give is spO2 is or becomes under 90% #LiverTwitter
@US_FDA Approves #Terlipressin to Improve Kidney Function in Hepatorenal Syndrome (HRS-AKI) #livertwitter www.pharmacytimes.com/view/fda-approves-terlip...
The results of the CONFIRM trial testing #terlipressin for #HRS were presented at the #LiverMtg19 this week.
COI: CONFIRM investigator, consultant for Mallinckrodt #hepatorenal #AKI
@AASLDtweets #terlipressin is clearly not a silver bullet for type 1 HRS and there are definitely significant AEs to contend with. Biggest disappointment in my mind was 31% reversal rate which I thought was closer to 40-45% (but different definitions) #LiverMtg19
@AASLDtweets #terlipressin caused more abdominal pain, resp. failure and more discontinuations. 2/200 had intestinal ischemia. #LiverMtg19
@AASLDtweets dr. Wong: #terlipressin meets primary endpoint of verified type 1 HRS reversal (31% vs 15% for placebo). Less patients need dialysis after transplant compared to placebo. No impact of survival #LiverMtg19
@AASLDtweets tomorrow’s #LiverMtg19 brings a long awaited practice changing dataset to the forefront at the late breaker session: #terlipressin for type 1 HRS $MNK
in typical topline press release fashion, info is scarce but the mere fact that #terlipressin met primary endpoint is exciting. Plans to file NDA in Q1 2020. More data #livermtg2019
" #terlipressin study met its primary endpoint of verified HRS-1 reversal (p=0.012). Verified HRS-1 reversal includes three components: renal function improvement, avoidance of dialysis and short-term survival"