Pharmacokinetic Analysis of Nicotine and Its Metabolites (Cotinine and trans-3'-Hydroxycotinine) in Male Sprague-Dawley Rats Following Nose-Only Inhalation, Oral Gavage, and Intravenous Infusion of Ni... Nicotine is an alkaloid found in tobacco. Human exposure to nicotine primarily occurs through the use of tobacco products. To date, limited nicotine pharmacokinetic data in animals have been reported....

New @toxsci paper from @fda.gov institutes improves our understanding of the pharmacokinetics of #nicotine & its metabolites cotinine, & 3-OH-cotinine across different routes of exposure.
#TobRegSci #TobSci

pubmed.ncbi.nlm.nih.gov/39270062/